Chocoholic mice fear no pain

February 9, 2010, BioMed Central

Ever get a buzz from eating chocolate? A study published in the open access journal BMC Neuroscience has shown that chocolate-craving mice are ready to tolerate electric shocks to get their fix.

Rossella Ventura worked with a team of researchers from the Santa Lucia Foundation, Rome, Italy, to study the links between stress and compulsive food-seeking. She said, “We used a new model of compulsive behavior to test whether a previous stressful experience of hunger might override a conditioned response to avoid a certain kind of food - in this case, chocolate”.

Ventura and her colleagues first trained well-fed and starved mice to seek chocolate in one chamber rather than going into an empty chamber. Then, they added a mild electric shock to the chamber containing the chocolate. Unsurprisingly, the well-fed animals avoided the sweet treat. 

However, mice that had previously been starved, before being allowed to eat their way back up their normal weight, resisted this conditioning - continuing to seek out despite the painful consequences. This is an index of and the researchers claim that this matches compulsive food seeking in the face of negative consequences in humans.

More information: Food seeking in spite of harmful consequences is under prefrontal cortical noradrenergic control, Emanuele Claudio Latagliata, Enrico Patrono, Stefano Puglisi-Allegra and Rossella Ventura, BMC Neuroscience 2010 11:15, doi:10.1186/1471-2202-11-15

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