Preventing HIV transmission during breastfeeding

October 20, 2010, University of Cambridge
Preventing HIV transmission during breastfeeding

In order to reduce the transmission of HIV from mother to baby during breastfeeding, scientists are developing a low-cost, modified nipple shield which dispenses antiviral compounds.

The novel research is highlighted in the following film.

Scientists at the University of Cambridge, with collaborators from the United States, are modifying a conventional nipple shield to include replaceable inserts. These inserts will contain an anti-viral agent which will be delivered to the infant while breastfeeding to prevent from an + mother.

They are currently exploring a number of cheap, edible microbicides which are deposited on the insert and released into the milk during breastfeeding, significantly reducing the HIV infectivity in the .

Breastfeeding accounts for up to one third of all mother-to-child transmissions of HIV, approximately 200,000 babies every year, primarily in Sub-Saharan Africa. Unfortunately, the mothers often have no alternative but to breastfeed as formula is typically even more deadly for the infant than the risk of HIV infection (due to the malnutrition and it often causes when used in low resource settings).

Stephen Gerrard, a PhD candidate at the Department of Chemical Engineering and Biotechnology at the University of Cambridge, stated: "The nipple shield could also deliver anti-retroviral drugs (ARVs) to non-infected infants - infant ARV prophylaxes (medicines given to prevent disease) is recommended by the if there is no acceptable, feasible, affordable, sustainable and safe alternative to breastfeeding for an HIV+ mother to her infant.

"This may also be an easier method of delivery than using oral syrup syringes, the current advised method of administration, and provide a new route for the delivery of many infant medications and nutritional supplements."

Explore further: Infant formula blocks HIV transmission via breastfeeding

More information: The 'JustMilk' project stemmed from the International Design Development Summit 2008, for more information visit hpp://justmilk.org .

Related Stories

Infant formula blocks HIV transmission via breastfeeding

July 3, 2008
Acquired Immune Deficiency Syndrome (AIDS) is a global epidemic threatening the lives of millions of people. Because there is no known cure, prevention of the transmission of the virus that causes AIDS, the Human Immunodeficiency ...

Zambian study finds longer breastfeeding best for HIV-infected mothers

January 14, 2010
A new study from Zambia suggests that halting breastfeeding early causes more harm than good for children not infected with HIV who are born to HIV-positive mothers. Stopping breastfeeding before 18 months was associated ...

ART therapy for babies, mothers safely reduces HIV transmission

July 22, 2009
Giving daily antiretroviral syrup to breastfeeding infants or treating their HIV-infected mothers with highly active antiretroviral drugs is safe and effective in preventing mother-to-child HIV transmission through breast ...

Extended infant antiretroviral prophylaxis reduces HIV risk during breastfeeding

June 5, 2008
In many resource-poor countries, infants born to mothers with HIV receive a single dose of nevirapine (NVP) and a one-week dose of zidovudine (ZDV) to prevent transmission of HIV from the mother to her newborn. The results ...

Breastfeeding now safer for infants of HIV-infected mothers

February 4, 2008
An antiretroviral drug already in widespread use in the developing world to prevent the transmission of HIV from infected mothers to their newborns during childbirth has also been found to substantially cut the risk of subsequent ...

Maternal HIV-1 treatment protects against transmission to newborns

October 16, 2009
Mothers receiving highly active antiretroviral therapy (HAART) to treat HIV-1 infection are less likely than untreated mothers to transmit the virus to their newborns through breastfeeding, according to a new study. The findings, ...

Recommended for you

Proof-of-concept HIV immunotherapy study passes Phase 1 safety trial

September 21, 2018
Preliminary results from a phase I clinical trial have demonstrated the safety and tolerability of a cell therapy involving the ex vivo expansion of T cells and their subsequent infusion into HIV-infected individuals previously ...

FRESH program combines basic science with social benefits for women at risk of HIV

September 14, 2018
A program established by investigators from the Ragon Institute of Massachusetts General Hospital (MGH), MIT and Harvard is addressing the persistently elevated risk of HIV infection among young women in South Africa from ...

New study finds HIV outbreak in Indiana could have been prevented

September 13, 2018
An HIV outbreak among people who inject drugs in Indiana from 2011 to 2015 could have been avoided if the state's top health and elected officials had acted sooner on warnings, a new study by the Yale School of Public Health ...

Largest study of 'post-treatment controllers' reveals clues about HIV remission

September 13, 2018
Most HIV patients need to take daily anti-retroviral therapy—if they suspend treatment, HIV will rebound within 3-4 weeks. But clinical trials have revealed that a small fraction of patients can stop taking medications ...

Very few sexually active gay and bisexual men use prophylactic drug to prevent HIV transmission, study finds

September 12, 2018
Only 4 percent of sexually active gay and bisexual men in the United States use Truvada, a highly effective medication used to prevent the transmission of HIV, according to the results of a first-of-its-kind study.

Special antibodies could lead to HIV vaccine

September 10, 2018
Around one percent of people infected with HIV produce antibodies that block most strains of the virus. These broadly acting antibodies provide the key to developing an effective vaccine against HIV. Researchers from the ...

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

junkd
not rated yet Nov 28, 2010
Reliable supplier, rapid delivery, guarantee!
http://star-of-he..._id=5831

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.