Daily home dialysis makes 'restless legs' better

March 17, 2011

For dialysis patients, performing daily dialysis at home can help alleviate sleep problems related to restless legs syndrome (RLS), according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). RLS, a common and troublesome problem for dialysis patients, affects hemodialysis patients about four times as often as people in the general population.

These results, from a study by lead author Bertrand L. Jaber, MD (St Elizabeth's Medical Center, Boston) and colleagues, add to the growing list of quality-of-life benefits received from home short daily hemodialysis (SDHD).

The preliminary report was part the FREEDOM study, which is evaluating SDHD as an alternative to dialysis center treatment. In SDHD, patients perform dialysis at home for a few hours, six days per week. "The FREEDOM Study is the largest U.S.-based observational study examining the potential clinical and economic benefits of home SDHD, which has witnessed an uptick in recent years," Jaber explains.

The researchers analyzed data on 235 patients to see how SDHD affected symptoms of RLS. Patients with RLS have abnormal feelings—such as "pins and needles" or crawling sensations—that are relieved by moving the legs. These feelings may lead to , such as insomnia and daytime sleepiness. Although the exact cause is unknown, RLS has been linked to increased rates of cardiovascular complications and death.

For the FREEDOM study patients, switching to SDHD led to significant improvement in RLS-related symptoms. "Over 12 months, there was decline in the percentage of patients reporting RLS and in those reporting moderate-to-severe symptoms," says Jaber. The patients also reported lasting improvement in sleep disorders—even after adjustment for the presence of RLS and for use of anti-anxiety and sedative drugs.

Future FREEDOM study results will determine how SDHD affects hospitalization rates and overall non-treatment related costs in patients.

The study had some important limitations including selection bias—evident by the recruitment of a relatively young (although not necessarily healthier) patient population. The absence of a control group is another important limitation, although the observed improvements in quality-of-life measures persisted beyond four months.

More information: The article, entitled "Impact of At-home Short Daily Hemodialysis on Restless Legs Symptoms and Sleep Disturbances" (doi:10.2215/CJN.10451110 ), will appear online on March 17, 2011.

Related Stories

Recommended for you

New compound stops progressive kidney disease in its tracks

December 7, 2017
Progressive kidney diseases, whether caused by obesity, hypertension, diabetes, or rare genetic mutations, often have the same outcome: The cells responsible for filtering the blood are destroyed. Reporting today in Science, ...

New Lyme disease tests could offer quicker, more accurate detection

December 7, 2017
New tests to detect early Lyme disease - which is increasing beyond the summer months -could replace existing tests that often do not clearly identify the infection before health problems occur.

Spinal tap needle type impacts the risk of complications

December 6, 2017
The type of needle used during a lumbar puncture makes a significant difference in the subsequent occurrence of headache, nerve irritation and hearing disturbance in patients, according to a study by Hamilton medical researchers.

Men with HPV are 20 times more likely to be reinfected after one year

December 5, 2017
A new analysis of genital human papillomavirus (HPV) in men shows that infection with one HPV type strongly increases the risk of reinfection with the same type. In fact, men who are infected with the type responsible for ...

New tuberculosis drugs possible with understanding of old antibiotic

December 5, 2017
Tuberculosis, and other life-threatening microbial diseases, could be more effectively tackled with future drugs, thanks to new research into an old antibiotic by the University of Warwick and The Francis Crick Institute.

Scientists create successful mass production system for bioengineered livers

December 5, 2017
Researchers report creating a biologically accurate mass-production platform that overcomes major barriers to bioengineering human liver tissues suitable for therapeutic transplant into people.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.