Treatment breakthrough for rare disease linked to diabetes

March 16, 2011, University of Manchester

University of Manchester scientists have led an international team to discover new treatments for a rare and potentially lethal childhood disease that is the clinical opposite of diabetes mellitus.

Congenital hyperinsulinism (CHI) is a condition where the body's pancreas produces too much insulin – rather than too little as in diabetes – so understanding the disease has led to breakthroughs in diabetes treatment.

This latest study, published in the journal Diabetes today (Wednesday), was carried out with clinical colleagues at hospitals throughout Europe and at the two referral centres for hyperinsulinism in the UK, the Royal Manchester Children's Hospital and Great Ormond Street Hospital, London.

"In healthy insulin-producing cells of the pancreas, a small group of proteins act as switches and regulate how much insulin is released," said Dr Karen Cosgrove, who led the research with Professor Mark Dunne in Manchester's Faculty of Life Sciences.

"When these proteins fail to function the cells can either release too little insulin – resulting in mellitus, or too much insulin – leading to congenital hyperinsulinism."

She continued: "CHI causes dangerously low blood sugar levels which can lead to convulsions and brain damage if not treated promptly. It is a complex condition caused by gene defects that keep the insulin-producing cells switched on when they should be switched off.

"Our group was the first to show how these gene defects led to uncontrolled insulin release in patients a number of years ago. Now we have taken the cells from patients following surgery and proven that, in some cases, it is possible to correct defects in the rogue cells."

Current drug treatments for CHI often fail in the most severe forms of the disease and the patient has to have some, or most, of their pancreas removed. The Manchester researchers discovered that treating cells under specially modified conditions helped to recover the function of the internal switches that control release. Through these experiments the team have provided the first evidence that the outcomes of gene defects can be reversed in human insulin-producing cells.

One of the drugs used in their studies is currently in clinical trials to treat patients with cystic fibrosis but has not been tested in patients with CHI. The team hope that their findings will pave the way for new or similar drugs to be used in clinical trials for hyperinsulinism.

"Although our results are really encouraging this is not a magic bullet for the treatment of this devastating condition, but it does offer real hope that in the future we may be able to use new drugs which can reverse the cellular defects," added Dr Cosgrove.

The clinical service at Royal Manchester Children's Hospital now includes state-of-the-art facilities for imaging the to detect hyperinsulinism. The clinical and academic teams work closely together within NorCHI (Northern Congenital Hyperinsulinism in Infancy service) to learn more about causes and treatments for this disease.

Related Stories

Recommended for you

Building better tiny kidneys to test drugs and help people avoid dialysis

February 16, 2018
A free online kidney atlas built by USC researchers empowers stem cell scientists everywhere to generate more human-like tiny kidneys for testing new drugs and creating renal replacement therapies.

Expanding Hepatitis C testing to all adults is cost-effective and improves outcomes

February 16, 2018
According to a new study, screening all adults for hepatitis C (HCV) is a cost-effective way to improve clinical outcomes of HCV and identify more infected people compared to current recommendations. Using a simulation model, ...

Study suggests expanded range for emerging tick-borne disease

February 16, 2018
Human cases of Borrelia miyamotoi, a tick-borne infection with some similarities to Lyme disease, were discovered in the eastern United States less than a decade ago. Now new research led by the Yale School of Public Health ...

Flu shot only 36 percent effective, making bad year worse (Update)

February 15, 2018
The flu vaccine is doing a poor job protecting older Americans and others against the bug that's causing most illnesses.

IFN-mediated immunity to influenza A virus infection influenced by RIPK3 protein

February 15, 2018
Each year, influenza kills half a million people globally with the elderly and very young most often the victims. In fact, the Centers for Disease Control and Prevention reported 37 children have died in the United States ...

A new class of drug to treat herpes simplex virus-1 infection

February 14, 2018
For patients with the herpes simplex-1 virus (HSV-1), there are just a handful of drugs available to treat the painful condition that can affect the eyes, mouth and genitals.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.