Mushroom compound suppresses prostate tumors

Mushroom compound suppresses prostate tumors
Dr. Patrick Ling says this is the first time the PSP compound has been proven to have anti-cancer stem cell effects. Credit: Erika Fish, QUT.

A mushroom used in Asia for its medicinal benefits has been found to be 100 per cent effective in suppressing prostate tumour development in mice during early trials, new Queensland University of Technology (QUT) research shows.

The compound, polysaccharopeptide (PSP), which is extracted from the 'turkey tail' mushroom, was found to target prostate cancer stem cells and suppress tumour formation in mice, an article written by senior research fellow Dr Patrick Ling in the international scientific journal said.

Dr Ling, from the Australian Prostate Cancer Research Centre-Queensland and Institute for Biomedical Health & Innovation (IHBI) at QUT, said the results could be an important step towards fighting a disease that kills 3000 Australian men a year.

"The findings are quite significant," Dr Ling said.

"What we wanted to demonstrate was whether that compound could stop the development of prostate tumours in the first place.

"In the past, other inhibitors tested in research trials have been shown to be up to 70 per cent effective, but we're seeing 100 per cent of this tumour prevented from developing with PSP.

"Importantly, we did not see any side effects from the treatment."

Dr Ling said conventional therapies were only effective in targeting certain cancer cells, not cancer , which initiated cancer and caused the disease to progress.

During the research trial, which was done in collaboration with The University of Hong Kong and Provital Pty Ltd, transgenic mice that developed prostate tumours were fed PSP for 20 weeks.

Dr Ling said no tumours were found in any of the mice fed PSP, whereas mice not given the treatment developed prostate tumours. He said the research suggested that PSP treatment could completely inhibit prostate tumour formation.

"Our findings support that PSP may be a potent preventative agent against prostate cancer, possibly through targeting of the stem cell population," he said.

He said PSP had been previously shown to possess anti-cancer properties, and 'turkey tail' mushrooms (known as Coriolus versicolor or Yun-zhi) had been widely used in Asia for medicinal benefits.

However, Dr Ling said it was the first time it had been demonstrated that PSP had anti-cancer stem cell effects.

Although 'turkey tail' had valuable health properties, Dr Ling said it would not be possible to get the same benefit his research showed from simply eating them.

Citation: Mushroom compound suppresses prostate tumors (2011, May 23) retrieved 25 April 2019 from https://medicalxpress.com/news/2011-05-mushroom-compound-suppresses-prostate-tumors.html
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Jun 19, 2011
The title of this article should read, "Mushroom compound suppresses prostate tumors IN MICE."

It would be nice to see some financially independent research here. Why can't the same benefit be obtained from simply eating turkey tail mushrooms, Dr. Ling? Explain, please.

A little insight from http://www.projec...e-label/
"Provital is the sole agent for selling Yunzhi PSP/Turkey Tail/ Mushroom compound in Australia." This same domain offers other exciting stuff, like "WATER REPLACES GASOLINE!" and "HOW TO MAKE MONEY WITH NSEARCH."

Caveat emptor. Follow the money, people.

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