EHJ paper underlines need for improved links between cardiologists and psychiatrists

November 15, 2011, European Society of Cardiology

People taking anti-psychotic drugs and anti-depressant drugs have a much higher risk of dying during an acute coronary event of a fatal arrhythmia than the rest of the population, finds a Finnish study published in the European Heart Journal.

The study showed that the combined use of both antipsychotic and was associated with an even greater risk of sudden cardiac death (SCD) during a .

"We've known for some time that mental disorders increase the risk of , but it hasn't been clearly established if psychiatric disorders, such as depression or schizophrenia, predispose to the occurrence of cardiovascular events or if they increase the patient's vulnerability to suffer fatal outcomes during the event. For the first time, this study has shown us that it is the increased vulnerability during the event that is the determining factor," said Heikki Huikuri, the study's principal investigator from the Institute of Clinical Medicine, University of Oulu (Oulu, Finland). "It points to an urgent need to improve screening for cardiovascular risk factors in psychiatric patients."

The study shows, he added, that where possible, the combination of anti-psychotic and anti-depressant medications should be avoided, and that off-label use of in the treatment of pain and sleep disorders should be restricted.

The study was part of the larger Finnish Genetic Study of Arrhythmic Events (FinGesture), a prospective case-control study designed to compare genetic and other risk profiles of the victims of sudden cardiac death with the survivors of acute coronary events. Between 1998 and 2009 FinGesture collected data on 2732 consecutive victims of out of hospital sudden death from an area in Northern Finland, with each case having autopsy confirmation of sudden during an acute coronary event. The control group was composed of 1256 patients treated at the University Hospital of Oulu who survived acute myocardial infarction. Information about the victims' latest medication was collected from medico legal autopsy reports and questionnaires answered by relatives.

The results showed that 9.7% of patients in the sudden death group had used antipsychotics in comparison to 2.4% in the control group (OR 4.4. 95% CI 2.9-6.6; P<0.001). For antidepressants 8.6 % of patients in the sudden death group had used this class of drugs compared to 5.5% in the control group (OR 1.6, 95% CI 1.2-2.2; P=0.003). Furthermore, results showed that combining phenothiazines and any antidepressant was associated with a very high risk of SCD (OR 18.3, 95% CI: 2.5 – 135.3<0.001).

The analysis showed that differences in the use of psychotropic medications between the two groups remained significant after adjusting for the use of cardiovascular drugs such as aspirin, beta blocking medication and angiotensin converting enzyme (ACE) inhibitors.

In the study, victims of SCD used both tricyclic anti-depressants (TCAs) and anti-psychotics more frequently, but excess use of selective serotonin reuptake inhibitors (SSRIs) and newer antidepressants was not found to be significant. "This clearly shows us that the mental disorder itself was not the reason for the association, but rather that it was the drugs used to treat these patients that made more probable," said Huikuri.

Some anti-psychotic drugs have been shown to cause prolongation of the QT interval in the electrocardiogram, which can lead to malignant polymorphic ventricular arrhythmias, torsades de pointes, and ultimately to sudden death. At the cellular level, drugs have be association with inhibition of potassium channels, which correlates with prolongation of the QT interval.

"There's a real need to ensure that drug safety studies for new antipsychotic and antidepressant medications are undertaken in conditions of ischemia to reflect the situation found in a myocardial infarction," said Josep Brugada, from Hospital Clinic of Barcelona, Spain, who was the author of the editorial accompanying the paper.

In the editorial, Brugada wrote that he believed psychotropic drug users represent a high risk population for coronary events due to the combination of two factors ². First they are at increased risk of suffering proarrhythmic effects from the drugs taken and second, they have an increased presence of classical cardiovascular risk factors. Studies, he said, have shown that these patients have a higher incidence of diabetes and dyslipidaemia than the general population, and are more likely to have hypertension and lead sedentary life styles. "I am convinced that it's the combination of these two factors which places this population at greater risk of cardiovascular death than the general population," he said.

Such observations point to the need for cardiologists and psychiatrists to establish reliable links between the two specialities. "Psychiatrists need to screen their patients routinely for and, if found to be high, refer to cardiologists," he said. "Equally, cardiologists should be alert for psychiatric problems and refer to psychiatrists. For patients with heart disease, guidelines need to be developed to establish which types of antipsychotic drugs and antidepressants should be used in different circumstances."

Explore further: Predictors of dying suddenly versus surviving heart attack identified

Related Stories

Predictors of dying suddenly versus surviving heart attack identified

July 25, 2011
Is it possible to predict whether someone is likely to survive or die suddenly from a heart attack?

Risk factors exposed for sudden cardiac death in post-menopausal women with coronary artery disease

August 1, 2011
A new study from the Perelman School of Medicine at the University of Pennsylvania indicates that post-menopausal women with coronary artery disease and other risk factors are at an increased risk for sudden cardiac death ...

Study uncovers novel genetic variation linked to increased risk of sudden cardiac arrest

June 30, 2011
A study by a global consortium of physician-scientists has identified a genetic variation that may predispose people to double the risk of having a sudden cardiac arrest, a disorder that gives little warning and is fatal ...

Recommended for you

Starting periods before age of 12 linked to heightened risk of heart disease and stroke

January 15, 2018
Starting periods early—before the age of 12—is linked to a heightened risk of heart disease and stroke in later life, suggests an analysis of data from the UK Biobank study, published online in the journal Heart.

'Decorated' stem cells could offer targeted heart repair

January 10, 2018
Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury - and getting them to stay there - remains challenging. In a new pilot study using an animal ...

Two simple tests could help to pinpoint cause of stroke

January 10, 2018
Detecting the cause of the deadliest form of stroke could be improved by a simple blood test added alongside a routine brain scan, research suggests.

Exercise is good for the heart, high blood pressure is bad—researchers find out why

January 10, 2018
When the heart is put under stress during exercise, it is considered healthy. Yet stress due to high blood pressure is bad for the heart. Why? And is this always the case? Researchers of the German Centre for Cardiovascular ...

Heart-muscle patches made with human cells improve heart attack recovery

January 10, 2018
Large, human cardiac-muscle patches created in the lab have been tested, for the first time, on large animals in a heart attack model. This clinically relevant approach showed that the patches significantly improved recovery ...

Place of residence linked to heart failure risk

January 9, 2018
Location. Location. Location.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.