Single-sex vaccination is most effective at reducing HPV infection

December 20, 2011, Public Library of Science

In this week's PLoS Medicine, Johannes Bogaards of VU University, the Netherlands and colleagues use mathematical models to investigate whether vaccinating females only, males only, or both sexes is the best way to achieve the most effective reduction in the population prevalence of sexually-transmitted infections.

Specifically for (HPV), the authors found that single-sex vaccination was the most effective strategy for prevention of disease and that it was preferable to vaccinate the sex with the highest prevaccine prevalence of HPV infection which for HPV is females.

The authors say: "Our results provide a justification, under most circumstances, for the intuitively plausible strategy of targeting intervention at the subgroups that harbor most infections and that act as a reservoir for transmission…We show that, once routine vaccination of one sex is in place, increasing the coverage in that sex is much more effective in bolstering herd immunity than switching to a policy that includes both sexes."

Explore further: Earlier male circumcision may help to slow rates of HIV, HPV transmission in South Africa

More information: Bogaards JA, Kretzschmar M, Xiridou M, Meijer CJLM, Berkhof J, et al. (2011) Sex-Specific Immunization for Sexually Transmitted Infections Such as Human Papillomavirus: Insights from Mathematical Models. PLoS Med 8(12): e1001147. doi:10.1371/journal.pmed.1001147

Related Stories

Earlier male circumcision may help to slow rates of HIV, HPV transmission in South Africa

October 6, 2011
According to Anna R. Giuliano, Ph.D., program leader in cancer epidemiology at Moffitt Cancer Center in Tampa, Fla., and colleagues in the Netherlands, earlier circumcision of males in South Africa may be a positive step ...

Safer-sex ed for women increases condom use, might reduce partners

April 13, 2011
Teaching young women how to prevent sexually transmitted infections (STIs) increases condom use and might reduce their number of sexual partners, but little research exists on whether educational programs reduce rates of ...

Cervical vaccine also protects against anal cancer risk

August 23, 2011
A vaccine routinely used to shield against cervical cancer caused by the human papillomavirus also reduces women's risk of anal cancer, a study published by the journal The Lancet Oncology on Tuesday says.

Recommended for you

Single blood test screens for eight cancer types

January 18, 2018
Johns Hopkins Kimmel Cancer Center researchers developed a single blood test that screens for eight common cancer types and helps identify the location of the cancer.

Researchers find a way to 'starve' cancer

January 18, 2018
Researchers at Vanderbilt University Medical Center (VUMC) have demonstrated for the first time that it is possible to starve a tumor and stop its growth with a newly discovered small compound that blocks uptake of the vital ...

How cancer metastasis happens: Researchers reveal a key mechanism

January 18, 2018
Cancer metastasis, the migration of cells from a primary tumor to form distant tumors in the body, can be triggered by a chronic leakage of DNA within tumor cells, according to a team led by Weill Cornell Medicine and Memorial ...

Modular gene enhancer promotes leukemia and regulates effectiveness of chemotherapy

January 18, 2018
Every day, billions of new blood cells are generated in the bone marrow. The gene Myc is known to play an important role in this process, and is also known to play a role in cancer. Scientists from the German Cancer Research ...

These foods may up your odds for colon cancer

January 18, 2018
(HealthDay)—Chowing down on red meat, white bread and sugar-laden drinks might increase your long-term risk of colon cancer, a new study suggests.

The pill lowers ovarian cancer risk, even for smokers

January 18, 2018
(HealthDay)—It's known that use of the birth control pill is tied to lower odds for ovarian cancer, but new research shows the benefit extends to smokers or women who are obese.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.