Potentially important new mechanisms found anti-aging effects of resveratrol

February 9, 2012

A well-conducted experimental study in mice has provided potentially important new insights into the association of the intake of resveratrol and like compounds with health benefits. Resveratrol is a constituent of red wine and other vegetable products, and is being evaluated in high-doses as a pharmaceutical. The biologic mechanisms demonstrated in this study could provide key new approaches for the prevention or treatment of a number of chronic diseases in humans, especially those related to vascular and metabolic diseases and to the risk of mortality.

More than two decades ago, particularly through publicity related to the so-called "French Paradox," the public became aware of the potential reduction in the risk of from the moderate consumption of red wine, and the media focused on a single constituent in red wine, , as being the "key" factor. We now know that resveratrol is only one of hundreds of in wine, many of which have been shown to have beneficial effects on vascular function, and that alcohol itself (present in wine, beer or spirits) also provides considerable protection against heart disease. Still, there has remained considerable attention paid to resveratrol, and extensive scientific research on resveratrol and related substances have shown that, in high doses, they may increase longevity of life and reduce of aging.

In general, Forum reviewers thought that this was a very well-done study. Their concerns related to the dose used in these experiments; while the levels of resveratrol and like compounds might be accessible with pharmaceutical doses, the suggestion that similar levels could be connected with is misleading. Further, in humans, resveratrol in the diet will interact with many other chemicals to achieve an effect, as whole consist of many active and inactive micronutrients that may play a role in health and disease. To ascribe a specific effect on health from one chemical found in wine or other plant products could be misleading.

Still, the reviewers believed that this paper was an important contribution to our knowledge about the mechanisms by which resveratrol and other chemicals may play a role in cardiovascular and other diseases. Such knowledge could help develop approaches for the prevention and treatment of human disease and for increasing the longevity of a healthy life.

Explore further: Red wine ingredient resveratrol stops breast cancer growth

More information: Park S-J, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H, Taussig R, Brown AL, Kim MK, Beaven MA, Burgin AB, Manganiello V, Chung JH. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 2012;148:421-433. DOI 10.1016/j.cell.2012.01.017

Related Stories

Red wine ingredient resveratrol stops breast cancer growth

September 29, 2011
Cheers! A new research report appearing in the October 2011 issue of The FASEB Journal shows that resveratrol, the "healthy" ingredient in red wine, stops breast cancer cells from growing by blocking the growth effects of ...

Red wine: Exercise in a bottle?

June 30, 2011
As strange as it sounds, a new research study published in the FASEB Journal, suggests that the "healthy" ingredient in red wine, resveratrol, may prevent the negative effects that spaceflight and sedentary lifestyles have ...

First clinical trial of red wine ingredient shows metabolic shifts

November 1, 2011
When obese men take a relatively small dose of resveratrol in purified form every day for a month, their metabolisms change for the better. In fact, the effects appear to be as good for us as severe calorie restriction. Resveratrol ...

Recommended for you

Hibernating ground squirrels provide clues to new stroke treatments

November 17, 2017
In the fight against brain damage caused by stroke, researchers have turned to an unlikely source of inspiration: hibernating ground squirrels.

Age and gut bacteria contribute to multiple sclerosis disease progression

November 17, 2017
Researchers at Rutgers Robert Wood Johnson Medical School published a study suggesting that gut bacteria at young age can contribute to multiple sclerosis (MS) disease onset and progression.

Molecular guardian defends cells, organs against excess cholesterol

November 16, 2017
A team of researchers at the Harvard T. H. Chan School of Public Health has illuminated a critical player in cholesterol metabolism that acts as a molecular guardian in cells to help maintain cholesterol levels within a safe, ...

Prototype ear plug sensor could improve monitoring of vital signs

November 16, 2017
Scientists have developed a sensor that fits in the ear, with the aim of monitoring the heart, brain and lungs functions for health and fitness.

Ancient enzyme could boost power of liquid biopsies to detect and profile cancers

November 16, 2017
Scientists are developing a set of medical tests called liquid biopsies that can rapidly detect the presence of cancers, infectious diseases and other conditions from only a small blood sample. Researchers at The University ...

FDA to crack down on risky stem cell offerings

November 16, 2017
U.S. health authorities announced plans Thursday to crack down on doctors pushing stem cell procedures that pose the gravest risks to patients amid an effort to police a burgeoning medical field that previously has received ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.