Esophageal reflux disease proton pump inhibitor therapy impact upon sleep disturbance

April 11, 2012, American Academy of Otolaryngology - Head and Neck Surgery

The use of proton pump inhibitors improves the sleep and daytime quality of life for sufferers of gastroesophageal reflux disease, according to a systematic literature review in the April 2012 issue of Otolaryngology–Head and Neck Surgery.

A 2003 Gallup survey linked gastresophageal heartburn with frequent . (PPIs) have proven to be an effective treatment therapy and there are established criteria for treating reflux. However, there are no well-established clinical guidelines on how to treat the sleep disturbances with the resulting quality of life issues.

The review's objective was to evaluate the "impact of PPI treatment of on sleep disturbance—related outcomes."

The authors performed a systematic literature review in PubMed, Web of Science, and the Cochrane Library of all randomized placebo-controlled clinical trials from 1989 (when omeprazole became available) to October 2011. Additional relevant publications were identified based on the articles' citations.

The search strategy identified all randomized placebo-controlled clinical trials published in English; both inhibitor use and outcome measures of sleep disturbance were reported for esophageal reflux disease patients. Using a preestablished systematic review protocol and data extraction format, four coauthors independently reviewed all articles.

Based on the review findings, the authors state: "The existing evidence supports the use of PPI medications as a treatment to improve esophageal reflux disease symptoms and associated sleep disturbance-related outcomes."

"Although the improvements are likely secondary gains from reduction or elimination of nocturnal GERD symptoms, further research appears warranted to evaluate PPI treatment impact on polysomnography outcomes, as well as to examine the relationship of polysomnography vs. nonpolysomnography outcomes, for GERD patients with sleep disturbance and sleep-disordered breathing," they added.

Explore further: Heartburn controlled with step down to once daily therapy

More information: "Esophageal Reflux Disease Proton Pump Inhibitor Therapy Impact upon Sleep Disturbance: A Systematic Review", Otolaryngology–Head and Neck Surgery.

Related Stories

Heartburn controlled with step down to once daily therapy

February 27, 2012
(HealthDay) -- The majority of gastroesophageal reflux disease (GERD) patients who take twice-daily proton pump inhibitor (PPI) therapy, are able to successfully step down to management of heartburn with a daily dose of dexlansoprazole ...

Acid reflux drug does not improve asthma in children

January 24, 2012
Children without symptoms of gastroesophageal reflux whose asthma was being poorly controlled with anti-inflammatory treatment did not have an improvement in symptoms or lung function with the added treatment of the proton ...

Recommended for you

Drug may help surgical patients stop opioids sooner

December 13, 2017
(HealthDay)—Opioid painkillers after surgery can be the first step toward addiction for some patients. But a common drug might cut the amount of narcotics that patients need, a new study finds.

Children best placed to explain facts of surgery to patients, say experts

December 13, 2017
Getting children to design patient information leaflets may improve patient understanding before they have surgery, finds an article in the Christmas issue of The BMJ.

Burn victim saved by skin grafts from identical twin (Update)

November 23, 2017
A man doomed to die after suffering burns across 95 percent of his body was saved by skin transplants from his identical twin in a world-first operation, French doctors said Thursday.

Is a common shoulder surgery useless?

November 21, 2017
(HealthDay)—New research casts doubt on the true effectiveness of a common type of surgery used to ease shoulder pain.

Study shows electric bandages can fight biofilm infection, antimicrobial resistance

November 6, 2017
Researchers at The Ohio State University Wexner Medical Center have shown - for the first time - that special bandages using weak electric fields to disrupt bacterial biofilm infection can prevent infections, combat antibiotic ...

Obesity increases incidence, severity, costs of knee dislocations

November 3, 2017
A new study of more than 19,000 knee dislocation cases in the U.S. between 2000 and 2012 provides a painful indication of how the nation's obesity epidemic is changing the risk, severity and cost of a traumatic injury.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.