ASCO: For chemo's nausea, olanzapine beats metoclopramide

ASCO: for chemo's nausea, olanzapine beats metoclopramide
(HealthDay) -- For patients receiving highly emetogenic chemotherapy who experience breakthrough chemotherapy-induced nausea and vomiting, treatment with olanzapine (Zyprexa) is significantly better than treatment with metoclopramide, according to a phase III study released May 16 in advance of presentation at the annual meeting of the American Society of Clinical Oncology, held from June 1 to 5 in Chicago.

Rudolph M. Navari, M.D., Ph.D., from the Indiana University School of Medicine South Bend, and colleagues conducted a randomized double-blind trial in chemotherapy-naive patients receiving highly emetogenic chemotherapy. Patients who developed breakthrough emesis or nausea, despite receiving guideline-recommended prophylactic treatment for chemotherapy-induced , were randomly allocated to receive (42 patients) or metoclopramide (38 patients) orally for three days. Patients were monitored for 72 hours after treatment.

During the 72-hour observation period, the researchers found that 71 percent of patients receiving olanzapine and 32 percent receiving metoclopramide had no emesis (P < 0.01). During the observation period, the proportion of patients without nausea was 67 percent of those treated with olanzapine versus 24 percent of those treated with (P < 0.01). The investigators noted no grade 3 or 4 toxicities.

"This study suggests that olanzapine will be very useful in these patients who feel very sick and sometimes come to the clinic, hospital, or emergency room. As a result, patients will feel better," Navari said in a statement.


Explore further

New research shows promise in treating cancer-related anorexia

More information: Abstract
More Information

Copyright © 2012 HealthDay. All rights reserved.

Citation: ASCO: For chemo's nausea, olanzapine beats metoclopramide (2012, May 17) retrieved 17 June 2019 from https://medicalxpress.com/news/2012-05-asco-chemo-nausea-olanzapine-metoclopramide.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more