One-fifth of healthy middle-aged men have low-grade murmur

May 25, 2012
One-Fifth of healthy middle-Aged men have low-Grade murmur

(HealthDay) -- More than one-fifth of healthy middle-aged men have a low-grade systolic heart murmur that confers a nearly five-fold higher risk of future aortic valve replacement (AVR), according to a study published in the June issue of the Journal of Internal Medicine.

Johan Bodegard, M.D., Ph.D., of the Oslo University Hospital in Norway, and colleagues conducted a study involving 2,014 healthy Norwegian men, aged 40 to 59 years, who underwent heart auscultation to detect systolic heart murmur along with other standard between 1972 and 1975. Of these, 1,541 (76.5 percent) had no heart murmur, 441 (21.9 percent) had a low-grade (grade I/II) murmur, and 32 (1.6 percent) had a moderate (grade III/IV) murmur. Patients were followed for up to 35 years to determine whether the presence of a low-grade systolic murmur was associated with an increased long-term risk of AVR or (CVD) mortality.

The researchers found that men with a low-grade systolic murmur had a 4.7-fold increased age-related risk of AVR, but no increased risk of mortality due to CVD. Men with a moderate-grade systolic murmur had an 89.3-fold increased risk of AVR and a 1.5-fold, but not statistically significant, increased risk of death due to CVD.

"Low-grade systolic murmur was found in more than one-fifth of apparently healthy middle-aged men with normal ," the authors write. "Men with low-grade systolic murmur have a late development of AVR requirement, and we suggest that an auscultatory follow-up at five years could safely replace an immediate referral for echocardiography."

Explore further: Middle-aged men with upper-normal blood pressure at risk for AF

More information: Abstract
Full Text (subscription or payment may be required)


Related Stories

Middle-aged men with upper-normal blood pressure at risk for AF

January 17, 2012
Middle-aged men at the upper end of normal blood pressure had an elevated risk for atrial fibrillation later in life, according to new research in Hypertension: Journal of the American Heart Association.

Diastolic dysfunction of the heart associated with increased risk of death

June 27, 2011
Individuals with diastolic dysfunction (an abnormality involving impaired relaxation of the heart's ventricle [pumping chamber] after a contraction) appear to have an increased risk of death, regardless of whether their systolic ...

Cardiovascular disease risk of high normal blood pressure decreases in old age

April 20, 2012
High normal blood pressure becomes less of a risk factor for incident cardiovascular disease (CVD) and coronary heart disease (CHD) with age, according to a new study presented today at the World Congress of Cardiology.

Recommended for you

Could this protein protect people against coronary artery disease?

November 17, 2017
The buildup of plaque in the heart's arteries is an unfortunate part of aging. But by studying the genetic makeup of people who maintain clear arteries into old age, researchers led by UNC's Jonathan Schisler, PhD, have identified ...

New model estimates odds of events that trigger sudden cardiac death

November 16, 2017
A new computational model of heart tissue allows researchers to estimate the probability of rare heartbeat irregularities that can cause sudden cardiac death. The model, developed by Mark Walker and colleagues from Johns ...

Popular e-cigarette liquid flavorings may change, damage heart muscle cells

November 16, 2017
Chemicals used to make some popular e-cigarette liquid flavorings—including cinnamon, clove, citrus and floral—may cause changes or damage to heart muscle cells, new research indicates.

Possible use for botulinum toxin to treat atrial fibrillation

November 16, 2017
From temporarily softening wrinkles to easing migraines, botulinum toxin has become a versatile medical remedy because of its ability to block nerve signals that can become bothersome or risky.

Proteome of the human heart mapped for the first time

November 15, 2017
A healthy heart beats about two billion times during a lifetime, thanks to the interplay of more than 10,000 proteins. Researchers from the Max Planck Institute of Biochemistry (MPIB) and the German Heart Centre at the Technical ...

First transcatheter implant for diastolic heart failure successful

November 15, 2017
Results presented today at the American Heart Association Scientific Sessions and published in Circulation show that a new device designed to treat diastolic heart failure is safe and effective. The first patient in the randomized, ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.