Study examines retinal vessel diameter and CVD risk in African Americans with type 1 diabetes

May 14, 2012

Among African Americans with type 1 diabetes mellitus, narrower central retinal arteriolar equivalent (average diameter of the small arteries in the retina) is associated with an increased risk of six-year incidence of any cardiovascular disease and lower extremity arterial disease, according to a report in the May issue of Archives of Ophthalmology.

"Retinal arteriolar narrowing has long been described as one of the characteristic changes associated with hypertension and cardiovascular disease (CVD)," the authors write as background information in the study.

Monique S. Roy, M.D., of the University of Medicine and Dentistry, New Jersey Medical School, The Institute of Ophthalmology and , Newark, N.J., and colleagues, sought to evaluate the relationship between retinal arteriolar and venular diameter and the six-year incidence of cardiovascular disease and mortality among African Americans with .

The study included 468 African Americans with mellitus who participated in the New Jersey 725 and had undergone a six-year follow-up examination. At both study entry and follow-up, hypertension and presence of heart disease, stroke or lower extremity arterial disease (LEAD) were documented and were confirmed by review of and medical records.

During the six-year follow-up, 59 patients developed CVD (37 with heart disease or stroke and 22 with LEAD), and 79 developed hypertension. The authors found that narrower central arteriolar equivalent (CRAE) at baseline was significantly and independently associated with six-year incidence of any cardiovascular disease and LEAD, as well as all cause mortality, while a larger retinal venular diameter was associated with six-year incidence of hypertension.

"In summary, results of the present study indicate that, in African Americans with type 1 DM, narrower CRAE is an independent predictor of the six-year incidence of any CVD and LEAD, and larger central retinal venular equivalent [CRVE] is an of the incidence of hypertension," the authors conclude.

Explore further: Retinal microvascular changes associated with disability in daily activities among older adults

More information: Arch Ophthalmol. 2012;130[5]:561-567

Related Stories

Retinal microvascular changes associated with disability in daily activities among older adults

November 14, 2011
Retinal microvascular changes appear to be associated with development of disability in performing activities of daily living among older adults, and retinal signs may be useful in predicting outcomes among this population, ...

Kids' 'screen time' linked to early markers for cardiovascular disease

April 20, 2011
Six-year-olds who spent the most time watching television, using a computer or playing video games had narrower arteries in the back of their eyes — a marker of future cardiovascular risk, in a first-of-its-kind study ...

Study finds air pollution linked to diabetes and hypertension in African-American women

January 5, 2012
(Boston) -The incidence of type 2 diabetes and hypertension increases with cumulative levels of exposure to nitrogen oxides, according to a new study led by researchers from the Slone Epidemiology Center (SEC) at Boston University. ...

Recommended for you

Coming soon: Glaucoma self-care, from home?

September 23, 2017
(HealthDay)—For many glaucoma patients, repeat trips to a doctor's office to check on their eyes can be a real pain.

Researchers identify potential biomarkers of age-related macular degeneration

September 12, 2017
Patients with any stage of age-related macular degeneration (AMD) carry signs of the disease in their blood that may be found through special laboratory tests, according to a new study led by AMD researchers based at Massachusetts ...

Researchers unlock regenerative potential of cells in the mouse retina

August 28, 2017
Cells within an injured mouse eye can be coaxed into regenerating neurons and those new neurons appear to integrate themselves into the eye's circuitry, new research shows. The findings potentially open the door to new treatments ...

Antioxidant supplement cost saving and effective for degenerative eye disease

August 24, 2017
A supplement that combines antioxidants with zinc and copper is a relatively inexpensive and effective means of halting the progression of a certain type of degenerative eye disease, concludes research published online in ...

Researchers identify key compounds to resolve abnormal vascular growth in AMD

August 21, 2017
A compound of specific bioactive products from a major family of enzymes reduced the severity of age-related macular degeneration (AMD) in a preclinical model, according to a new study led by Massachusetts Eye and Ear researchers. ...

World's blind population to soar: study

August 3, 2017
The world's blind will increase threefold from about 36 million today to 115 million in 2050 as populations expand and individuals grow ever older, researchers said Thursday.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.