Hemoglobin A1C inadequate for postpartum diabetes screening

June 19, 2012
Hemoglobin A1C inadequate for postpartum diabetes screening
For postpartum women who have had gestational diabetes mellitus, the hemoglobin A1c test criteria alone or in combination with fasting glucose test criteria does not provide sensitive and specific diagnosis of abnormal carbohydrate metabolism compared with the gold-standard oral glucose tolerance test, according to a study published online June 11 in Diabetes Care.

(HealthDay) -- For postpartum women who have had gestational diabetes mellitus (GDM), the hemoglobin A1c (A1C) test criteria alone or in combination with fasting glucose test criteria does not provide sensitive and specific diagnosis of abnormal carbohydrate metabolism compared with the gold-standard oral glucose tolerance test (OGTT), according to a study published online June 11 in Diabetes Care.

María José Picón, M.D., Ph.D., of the Virgen de la Victoria University Hospital in Malaga, Spain, and colleagues measured the sensitivity and positive predictive value (PPV) of the A1C test, with or without the fasting glucose test, compared with the OGTT in 231 postpartum women with prior GDM one year after delivery.

The researchers found that, based on the OGTT, A1C test, fasting glucose test, and A1C-fasting glucose test criteria, the prevalence of abnormal was 45.89, 19.05, 38.10, and 46.75 percent, respectively. Compared with the OGTT, the A1C test had a sensitivity and PPV of 22.64 and 54.55 percent, respectively; while the fasting glucose criterion had a sensitivity and PPV of 83.02 and 100 percent, respectively. Using both together, the sensitivity and PPV were 83.02 and 81.48 percent, respectively; and these criteria classified 18 women with normal carbohydrate metabolism as having abnormal carbohydrate metabolism.

"In summary, the A1C test significantly underdiagnosed carbohydrate metabolism disorders in women who had had GDM," the authors write.

Explore further: New NIH fact sheet explains test for diabetes, prediabetes

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

New NIH fact sheet explains test for diabetes, prediabetes

January 27, 2012
A new fact sheet from the National Institutes of Health explains the A1C test, a widely used and important test to diagnose type 2 diabetes and prediabetes, and to monitor blood glucose levels of people with type 1 and type ...

Gestational diabetes, obesity impact pregnancy outcomes

March 2, 2012
(HealthDay) -- Women with gestational diabetes mellitus (GDM) who are obese have significantly higher odds of adverse pregnancy outcomes, according to findings from the multinational Hyperglycemia and Adverse Pregnancy Outcome ...

American Diabetes Association's preferred testing method fails to identify kids with diabetes

November 21, 2011
In 2009, the American Diabetes Association (ADA) recommended that Hemoglobin A1c be exclusively used for the diagnosis of diabetes in children. The simple test measures longer-term blood sugar levels -- without requiring ...

2 tests better than 1 to diagnose diabetes in overweight children

May 2, 2011
A new study found that the recommended blood test may not be enough to catch type 2 diabetes in overweight children, missing more than two-thirds of children at high-risk for the condition. Researchers from Children's Mercy ...

Recommended for you

Finding a natural defense against clogged arteries

September 20, 2017
In type 2 diabetes, chronic inflammation drives cardiovascular disease, the leading cause of death among people with the condition. Researchers at Joslin Diabetes Center now have identified an unexpected natural protective ...

Study identifies blood vessel as a therapeutic target for diabetes

September 14, 2017
Blood vessels have an often overlooked role of regulating the transfer of nutrients from the blood to organs in the body. In a new Yale-led study, researchers have identified a role of a secreted protein, apelin, in regulating ...

Drug for type 2 diabetes provides significant benefits to type 1 diabetic patients

September 14, 2017
A majority of patients with Type 1 diabetes who were treated with dapagliflozin, a Type 2 diabetes medicine, had a significant decline in their blood sugar levels, according to a new study published in The Lancet Diabetes ...

Could swine flu be linked to type 1 diabetes?

September 14, 2017
(HealthDay)—Young people who've been infected with the H1N1 swine flu virus may be at increased risk for type 1 diabetes, a new study suggests.

Epigenetic 'fingerprint' identifies diabetes risk

September 14, 2017
Deakin researchers have identified an epigenetic marker that predicts risk of type 2 diabetes in women with gestational diabetes.

Time to dial back on diabetes treatment in older patients? Study finds 11 percent are overtreated

September 14, 2017
Anyone with diabetes who takes blood sugar medication knows their doctor prescribed it to help them. After all, the long-term effects of elevated blood sugar can harm everything from the heart and kidneys to the eyes and ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.