Nomogram developed to estimate early breast cancer survival

June 27, 2012
Nomogram developed to estimate early breast cancer survival
A nomogram has been developed to predict five- and 10-year mastectomy-free survival in older women with early breast cancer and estimate the predicted benefit of radiation therapy following conservative surgery, according to research published online June 25 in the Journal of Clinical Oncology.

(HealthDay) -- A nomogram has been developed to predict five- and 10-year mastectomy-free survival (MFS) in older women with early breast cancer and estimate the predicted benefit of radiation therapy (RT) following conservative surgery (CS), according to research published online June 25 in the Journal of Clinical Oncology.

In an effort to develop a to predict five- and 10-year MFS rates with and without RT, Jeffrey M. Albert, M.D., of the University of Texas MD Anderson Cancer Center in Houston, and colleagues utilized population-based data from 16,092 women aged 66 to 79 years who participated in the Surveillance, Epidemiology and End Results Program.

The researchers found that overall five- and 10-year MFS rates were 98.1 and 95.4 percent, respectively, after a median follow-up period of 7.2 years. Significant predictors of time to mastectomy included age, race, , estrogen receptor status, receipt of radiotherapy, and nodal status. The nomogram developed was able to accurately predict MFS.

"In summary, we used population-based data to develop a nomogram to estimate five- and 10-year MFS among older women with early treated with CS," the authors write. "This clinically useful tool uses readily available clinicopathologic factors to estimate the probability of MFS and can further aid individualized clinical decision making by estimating the potential benefit from RT for this large and growing patient population."

One study author disclosed a financial tie to Varian Medical Systems, which contributed funding to the study.

Explore further: New tool helps identify prostate cancer patients with highest risk of death

More information: Abstract
Full Text (subscription or payment may be required)
Editorial

Related Stories

New tool helps identify prostate cancer patients with highest risk of death

October 5, 2011
After a prostate cancer patient receives radiation treatment, his doctor carefully monitors the amount of prostate-specific antigen, or PSA, in his blood. An increase in PSA, called biochemical failure, is the first detectable ...

Young women with early breast cancer have similar survival with breast conservation, mastectomy

September 7, 2011
Young women with early-stage breast cancer have similar survival rates with a lumpectomy and radiation treatment, known as breast-conservation therapy, as with mastectomy, a new study conducted at the University of Maryland ...

Recommended for you

Zebrafish larvae could be used as 'avatars' to optimize personalized treatment of cancer

August 21, 2017
Portuguese scientists have for the first time shown that the larvae of a tiny fish could one day become the preferred model for predicting, in advance, the response of human malignant tumors to the various therapeutic drugs ...

Scientists discover vitamin C regulates stem cell function, curbs leukemia development

August 21, 2017
Not much is known about stem cell metabolism, but a new study from the Children's Medical Center Research Institute at UT Southwestern (CRI) has found that stem cells take up unusually high levels of vitamin C, which then ...

Searching for the 'signature' causes of BRCAness in breast cancer

August 21, 2017
Breast cancer cells with defects in the DNA damage repair-genes BRCA1 and BRCA2 have a mutational signature (a pattern of base swaps—e.g., Ts for Gs, Cs for As—throughout a genome) known in cancer genomics as "Signature ...

How a non-coding RNA encourages cancer growth and metastasis

August 21, 2017
A mechanism that pushes a certain gene to produce a non-coding form of RNA instead of its protein-coding alternative can promote the growth of cancer, report researchers at the Medical University of South Carolina (MUSC) ...

Spaser can detect, kill circulating tumor cells to prevent cancer metastases, study finds

August 21, 2017
A nanolaser known as the spaser can serve as a super-bright, water-soluble, biocompatible probe capable of finding metastasized cancer cells in the blood stream and then killing these cells, according to a new research study.

Comprehensive genomic analysis offers insights into causes of Wilms tumor development

August 21, 2017
A comprehensive genomic analysis of Wilms tumor - the most common kidney cancer in children - found genetic mutations involving a large number of genes that fall into two major categories. These categories involve cellular ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.