Celiac disease linked to lymphoproliferative disorders

July 26, 2012
Celiac disease linked to lymphoproliferative disorders
Patients with celiac disease, particularly those presenting with malabsorption symptoms later in life, have a higher incidence of lymphoproliferative disorders, according to research published in the August issue of the American Journal of Hematology.

(HealthDay) -- Patients with celiac disease, particularly those presenting with malabsorption symptoms later in life, have a higher incidence of lymphoproliferative disorders (LPDs), according to research published in the August issue of the American Journal of Hematology.

Lori A. Leslie, M.D., of the Columbia University Medical Center in New York City, and colleagues conducted a involving 1,285 adults with biopsy-proven celiac disease seen at a U.S. referral center from 1981 to 2010 to determine the incidence of LPD subtypes and survival according to LPD subtype.

The researchers identified 40 patients who developed LPD (standardized incidence ratio [SIR], 6.48), including 33 with non-Hodgkin's lymphoma (NHL; SIR, 6.91). Significantly elevated associations were see for the incidences of enteropathy-associated T-cell (EATL), non-EATL T-cell, diffuse large B-cell, mantle cell, and marginal zone lymphoma subtypes of NHL when only those diagnosed with celiac before LPD were considered. Patients with EATL had a shorter average survival compared with non-EATL patients. Patients who developed LPD were more likely to present with diarrhea, , and/or weight loss and were older at the time of celiac diagnosis (57.9 versus 42.5 years).

"In the future, the association between celiac disease and various LPD subtypes could be further analyzed to identify common molecules in the inflammatory and lymphoproliferative pathways as promising targets for drug design," the authors write. "These findings could then be studied to risk stratify patients with regard to lymphoma, devise surveillance protocols, and propose preventative strategies in celiac disease with increased risk of developing LPD."

Explore further: Increased celiac disease prevalence in women with unexplained infertility

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Increased celiac disease prevalence in women with unexplained infertility

August 18, 2011
A recent study demonstrated increased rates of celiac disease in women who present with unexplained infertility. Published in the May-June 2011 issue of The Journal of Reproductive Medicine, the study evaluated 191 female ...

Low adherence to biopsy guidelines affects celiac disease diagnosis in the United States

July 7, 2011
A new study has found that most patients undergoing biopsy of the small intestine do not have the recommended number of samples to diagnose celiac disease. The study, published in the July 2011 issue of Gastrointestinal ...

Medical follow-up in celiac disease is less than optimal

July 25, 2012
Follow-up exams for patients with celiac disease are often inadequate and highly variable, according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological ...

Socioeconomic status influences celiac disease diagnosis

May 8, 2011
Income is a pivotal factor in whether a patient without common symptoms of celiac disease is accurately diagnosed with the digestive condition, according to a new study from the Beth Israel Deaconess Medical Center in Boston, ...

New study finds low rates of biopsy contribute to celiac disease underdiagnosis in US

June 29, 2012
Under-performance of small bowel biopsy during endoscopy may be a major reason that celiac disease remains underdiagnosed in the United States, according to a new study published online recently in Gastrointestinal Endoscopy. ...

Recommended for you

Two Group A Streptococcus genes linked to 'flesh-eating' bacterial infections

September 22, 2017
Group A Streptococcus bacteria cause a variety of illnesses that range from mild nuisances like strep throat to life-threatening conditions including pneumonia, toxic shock syndrome and the flesh-eating disease formally known ...

Ecosystem approach makes urinary tract infection more treatable

September 22, 2017
The biological term 'ecosystem' is not usually associated with urinary tract infections, but this should change according to Wageningen scientists.

Residents: Frontline defenders against antibiotic resistance?

September 22, 2017
Antibiotic resistance continues to grow around the world, with sometimes disastrous results. Some strains of bacteria no longer respond to any currently available antibiotic, making death by infections that were once easily ...

Superbug's spread to Vietnam threatens malaria control

September 21, 2017
A highly drug resistant malaria 'superbug' from western Cambodia is now present in southern Vietnam, leading to alarming failure rates for dihydroartemisinin (DHA)-piperaquine—Vietnam's national first-line malaria treatment, ...

Investigators may unlock mystery of how staph cells dodge the body's immune system

September 21, 2017
For years, medical investigators have tried and failed to develop vaccines for a type of staph bacteria associated with the deadly superbug MRSA. But a new study by Cedars-Sinai investigators shows how staph cells evade the ...

Individualized diets for irritable bowel syndrome better than placebo

September 21, 2017
Patients with irritable bowel syndrome who follow individualized diets based on food sensitivity testing experience fewer symptoms, say Yale researchers. Their study is among the first to provide scientific evidence for this ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.