Clinical trial for OVA1 blood test showing promising results for detecting ovarian cancer

July 31, 2012 by Bob Yirka weblog

(Medical Xpress) -- Researchers at Vermillion, a medical diagnostics company have announced that clinical trials for its OVA1® blood test diagnostic tool have shown promising results. The tool, part of Vermillion’s OVA500 program is aimed at developing tests that provide doctors and patients with better information regarding whether ovarian growth’s (tumors) are cancerous or simply benign cysts, prior to surgery.

OVA1 was first approved for back in 2009, giving a hint as to why such tests tend to cost so much once they are finally approved. Lumps or tumors in ovaries are generally first discovered by manual manipulation of the pelvis by a doctor; unfortunately, the discovery doesn’t allow them to fully understand their nature without resorting to a biopsy. A that could reveal the type of tumor would save time, money and emotional stress for patients. If approved for use by doctors, OVA1 would allow a medical professional to take a small blood sample at the time that any unusual changes in the ovary are noticed. Testing involves using software analysis of the sample using proprietary algorithms developed by Vermillion, it performs calculations on five immunoassays and produces a number that indicates the likelihood of a tumor of being malignant. In the trials, which are conducted independent of Vermillion, 494 patients were involved in the most recent trial (a thousand have participated overall) with the focus on women already diagnosed with still in the early stages and those that are premenopausal. The premenopausal group was included in the study because few women in that group get that type of cancer but a lot of them get benign cysts.

Overall it appears OVA1 did quite well, finding a sensitivity of 94% for the premenopausal patients and 91% for those who were known to have early stage cancers. The percentages indicate the ability of the blood test to detect cancer (or rule it out) in the people tested. In addition, false positives were rated as very low (just 2%).

The announcement caused shares of Vermillion stock to rise significantly, but more importantly, suggests that the blood test works as advertised which means that someday soon, women may perhaps be spared the torment of undergoing a surgical procedure and then worse perhaps, waiting two or more days for the results, when all they actually have is a benign cyst.

Explore further: FDA clears biomarker test for ovarian cancer

More information: Press release

Related Stories

FDA clears biomarker test for ovarian cancer

September 6, 2011
Approval last week by U.S. Food and Drug Administration (FDA) clears the path for nationwide use of tools that show the greatest specificity in estimating the risk of ovarian cancer in women with a pelvic mass.

U.S. panel rejects ovarian cancer screening

April 10, 2012
(HealthDay) -- A leading U.S. government panel has renewed its 2004 recommendation that women at average risk for ovarian cancer not get screened for the disease.

New blood test for early cancer detection developed

February 21, 2012
A simple blood test is being developed by researchers at Ben-Gurion University of the Negev (BGU) and Soroka University Medical Center in Beer-Sheva, Israel that may provide early detection of many types of cancer.

Recommended for you

Glioblastoma survival mechanism reveals new therapeutic target

December 11, 2017
A Northwestern Medicine study, published in the journal Cancer Cell, has provided new insights into a mechanism of tumor survival in glioblastoma and demonstrated that inhibiting the process could enhance the effects of radiation ...

A new weapon against bone metastasis? Team develops antibody to fight cancer

December 11, 2017
In the ongoing battle between cancer and modern medicine, some therapeutic agents, while effective, can bring undesirable or even dangerous side effects. "Chemo saves lives and improves survival, but it could work much better ...

Scientists discover possible master switch for programming cancer immunotherapy

December 11, 2017
During infection or tumor growth, a type of specialized white blood cells called CD8+ T cells rapidly multiply within the spleen and lymph nodes and acquire the ability to kill diseased cells. Some of these killer T cells ...

Liver cancer: Lipid synthesis promotes tumor formation

December 11, 2017
Lipids comprise an optimal energy source and an important cell component. Researchers from the Biozentrum of the University of Basel and from the University of Geneva have now discovered that the protein mTOR stimulates the ...

Use of chemotherapy for early stage breast cancer declines, study says

December 11, 2017
A study of nearly 3,000 women with early stage breast cancer indicates a recent, significant decline in the use of chemotherapy despite the lack of any change in national treatment recommendations or guidelines, according ...

Researchers identify epigenetic orchestrator of pancreatic cancer cells

December 11, 2017
Genentech researchers have identified an enzyme that shifts pancreatic cancer cells to a more aggressive, drug-resistant state by epigenetically modifying the cells' chromatin. The study, which will be published December ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.