Good long-term limb salvage for diabetic foot patients

July 29, 2012
Good long-term limb salvage for diabetic foot patients
For patients with diabetic foot ulcers, long-term limb salvage is favorable; however, long-term survival remains poor, particularly for those with peripheral artery disease or chronic renal insufficiency, according to a study published online July 18 in Diabetes Care.

(HealthDay) -- For patients with diabetic foot ulcers (DFUs), long-term limb salvage is favorable; however, long-term survival remains poor, particularly for those with peripheral artery disease (PAD) or chronic renal insufficiency, according to a study published online July 18 in Diabetes Care.

To assess the correlation between patient and limb survival in patients with DFUs, Stephan Morbach, M.D., of the Marienkrankenhaus in Soest, Germany, and colleagues conducted a prospective study involving 247 consecutive patients with DFUs and without previous major amputation. Participants (mean age 68.8 years; 58.7 percent male; 55.5 with PAD) presented between June 1998 and December 1999 and were followed until May 2011.

The researchers found that 15.4 percent of patients experienced a first major amputation during follow-up. PAD was present in 37 of these 38 patients at study inclusion, and 51.4 percent had severe PAD. Significant predictors for the first major amputation included age (hazard ratio [HR], 1.05 per year), dialysis (HR, 3.51), and PAD (HR, 35.34). At years one, three, five, and 10, cumulative were 15.4, 33.1, 45.8, and 70.4 percent, respectively. Death in these patients was significantly predicted by increasing age (HR, 1.08 per year), (HR, 1.83), dialysis (HR, 6.43), and PAD (HR, 1.44).

"In conclusion, data from this long-term study suggest strongly that limb preservation today is the rule rather than the exception, even in high-risk patients with diabetes," the authors write. "Long-term survival remains poor, however, probably because of myriad comorbid conditions for patients whose first presentation to an interdisciplinary clinic is with a diabetic foot ulcer."

Explore further: Depression linked to greater risk of peripheral artery disease

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Depression linked to greater risk of peripheral artery disease

April 20, 2012
Depression may be associated with an increased risk of arterial narrowing in the legs and pelvis, a condition known as peripheral artery disease (PAD), according to research presented at the American Heart Association's Arteriosclerosis, ...

New angioplasty procedure improves blood flow in blocked arteries to extremities

July 24, 2012
Patients with blocked arteries to their extremities, known as peripheral artery disease (PAD) or critical limb ischemia (CLI), may now find relief from lower leg pain and wounds caused by impaired leg artery circulation with ...

Bortezomib ups response, survival in multiple myeloma

July 23, 2012
(HealthDay) -- For patients with newly diagnosed multiple myeloma (MM), induction treatment with a combination of bortezomib, doxorubicin, and dexamethasone (PAD) followed by bortezomib maintenance therapy improves complete ...

Recommended for you

Alzheimer's drug cuts hallmark inflammation related to metabolic syndrome by 25 percent

July 20, 2017
An existing Alzheimer's medication slashes inflammation and insulin resistance in patients with metabolic syndrome, a potential therapeutic intervention for a highly dangerous condition affecting 30 percent of adults in the ...

Diabetes or its precursor affects 100 million Americans

July 19, 2017
Almost one-third of the US population—100 million people—either has diabetes or its precursor condition, known as pre-diabetes, said a government report Tuesday.

One virus may protect against type 1 diabetes, others may increase risk

July 11, 2017
Doctors can't predict who will develop type 1 diabetes, a chronic autoimmune disease in which the immune system destroys the cells needed to control blood-sugar levels, requiring daily insulin injections and continual monitoring.

Diabetes complications are a risk factor for repeat hospitalizations, study shows

July 7, 2017
For patients with diabetes, one reason for hospitalization and unplanned hospital readmission is severe dysglycemia (uncontrolled hyperglycemia - high blood sugar, or hypoglycemia - low blood sugar), says new research published ...

Researchers identify promising target to protect bone in patients with diabetes

July 7, 2017
Utilizing metabolomics research techniques, NYU Dentistry researchers investigated the underlying biochemical activity and signaling within the bone marrow of hyperglycemic mice with hopes of reducing fracture risks of diabetics

Immune system killer cells increase risk of diabetes

July 6, 2017
More than half of the German population is obese. One effect of obesity is to chronically activate the immune system, placing it under continuous stress. Researchers in Jens Brüning's team at the Max-Planck-Institute for ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.