Azathioprine may benefit pediatric atopic dermatitis

August 21, 2012
Azathioprine may benefit pediatric atopic dermatitis
For pediatric patients with refractory atopic dermatitis, oral azathioprine is associated with clinical improvement, and measurement of thiopurine methyltransferase activity seems useful for monitoring treatment, according to a study published online Aug. 13 in the Journal of the American Academy of Dermatology.

(HealthDay) -- For pediatric patients with refractory atopic dermatitis (AD), oral azathioprine is associated with clinical improvement, and measurement of thiopurine methyltransferase (TPMT) activity seems useful for monitoring treatment, according to a study published online Aug. 13 in the Journal of the American Academy of Dermatology.

To examine appropriate use and monitoring of azathioprine for children with AD, Maura Caufield, from the Georgetown University School of Medicine in Washington, D.C., and Wynnis L. Tom, M.D., from the University of California in San Diego, prospectively followed 12 children with severe, recalcitrant AD who were treated with oral azathioprine. At baseline, TPMT activity was measured, and, at times of stable improvement, inadequate response, or change in response, the measurement was repeated, together with measurement of 6-thioguanine nucleotide and 6-methylmercaptopurine.

The researchers found that, for all but one patient, therapy correlated with clinical improvement, with few adverse effects. During treatment, three patients exhibited significant changes in TPMT activity: two had a mild decrease and one demonstrated enzyme inducibility, with enzyme activity increasing from intermediate to normal range. There was an inverse correlation between these changes and to therapy, which was not seen for 6-thioguanine nucleotide or 6-methylmercaptopurine levels.

"Our results suggest that TPMT activity can alter in either direction during treatment," the authors write. "Repeated measurement might be warranted, particularly in cases of nonresponse to treatment, to optimize dosing or to consider alternate therapy."

Explore further: Methotrexate and azathioprine equally efficacious for eczema

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Methotrexate and azathioprine equally efficacious for eczema

April 6, 2012
(HealthDay) -- Methotrexate and azathioprine may be equally effective in treating severe atopic eczema in adults, according to a critical appraisal of a study published in the April issue of the British Journal of Dermatology.

Genetic-screening trial could reduce drug side-effects

June 24, 2011
(Medical Xpress) -- Patients with a range of common inflammatory diseases that also have genetic variations leading to low levels of a particular enzyme in their bodies are at greater risk of suffering side-effects from the ...

Study: Mycophenolate is superior to azathioprine as treatment for lupus nephritis

November 16, 2011
A new large, international study finds that the immunosuppressant drug mycophenolate mofetil is superior to azathioprine, an older immunosuppressant, as a maintenance therapy for lupus nephritis.

Recommended for you

New insights into the world of trypanosomes

August 23, 2017
Single specimens of the vermicular pathogens causing sleeping sickness swim inside the gut of the tsetse fly between blood cells which the fly has ingested from an infected mammal. This is where they start their week-long ...

Survey of DNA fragments circulating in the blood suggests vast microbial diversity

August 23, 2017
A new survey of DNA fragments circulating in human blood suggests our bodies contain vastly more diverse microbes than anyone previously understood. What's more, the overwhelming majority of those microbes have never been ...

Study a breakthrough in understanding chronic pain in children

August 23, 2017
A University of Calgary psychologist who studies pediatric pain has made a breakthrough in understanding the cause of chronic pain in adolescents—by focusing on those recovering from major surgeries.

Scientists develop infection model for tickborne flaviviruses

August 22, 2017
National Institutes of Health (NIH) scientists have filled a research gap by developing a laboratory model to study ticks that transmit flaviviruses, such as Powassan virus. Powassan virus was implicated in the death of a ...

Zika virus stifles pregnant women's weakened immune system to harm baby, study finds

August 21, 2017
The Zika virus, linked to congenital birth defects and miscarriages, suppresses a pregnant woman's immune system, enabling the virus to spread and increasing the chances an unborn baby will be harmed, a Keck School of Medicine ...

Fatty liver can cause damage to other organs via crosstalk

August 21, 2017
Nonalcoholic fatty liver disease is increasingly common. Approximately every third adult in industrialized countries has a morbidly fatty liver. This not only increases the risk of chronic liver diseases such as liver cirrhosis ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.