Long-term type 2 diabetes ups pancreatic cancer mortality

August 15, 2012
Long-term type 2 diabetes ups pancreatic cancer mortality
Among patients with pancreatic adenocarcinoma, those with pre-existing type 2 diabetes mellitus for longer than five years have an increased mortality risk, according to a study published online Aug. 1 in Cancer.

(HealthDay) -- Among patients with pancreatic adenocarcinoma (PAC), those with pre-existing type 2 diabetes mellitus (T2DM) for longer than five years have an increased mortality risk, according to a study published online Aug. 1 in Cancer.

To assess the effect of varying durations of pre-existing T2DM on survival, Allen Hwang, M.D., of the University of Pennsylvania in Philadelphia, and colleagues conducted a using data from The Health Improvement Network medical record database (2003 to 2010) for 3,147 patients with PAC. Of these, 745 had pre-existing T2DM and 2,402 did not.

In the primary analysis, the researchers found that there was no survival difference for those with and without pre-existing T2DM (hazard ratio, 1.02; P = 0.620). In a secondary analysis, significantly increased mortality was seen for patients with T2DM of more than five years duration (hazard ratio, 1.16; P < 0.05).

"In summary, we observed a significant increase in overall mortality in patients with a long-standing duration of T2DM (greater than five years)," the authors write. "The implications of these results are magnified by the growing prevalence of diabetes mellitus, the incidence of which has been increasing over the past two decades and is expected to nearly double over the next 25 years."

Explore further: Absolute incretin effect reduced in type 2 diabetes

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Absolute incretin effect reduced in type 2 diabetes

June 25, 2012
(HealthDay) -- For patients with type 2 diabetes mellitus (T2DM) the absolute incretin effect is reduced compared with healthy individuals, but its relative importance is increased, particularly in first-phase insulin secretion, ...

Aspirin enhances platelet isoprostanes in type 2 diabetes

March 23, 2012
(HealthDay) -- For patients with type 2 diabetes mellitus (T2DM) who are treated with aspirin, isoprostanes are overproduced, which is linked with enhanced platelet recruitment, according to a study published online March ...

Brain connectivity altered in type 2 diabetes

August 1, 2012
(HealthDay) -- Patients with type 2 diabetes mellitus (T2DM) have reduced functional connectivity in the default mode network, which is associated with insulin resistance in some brain regions, according to a study published ...

Recommended for you

Researchers identify gene variants linked to a high-risk children's cancer

September 25, 2017
Pediatric researchers investigating the childhood cancer neuroblastoma have identified common gene variants that raise the risk of an aggressive form of that disease. The discovery may assist doctors in better diagnosing ...

Prostaglandin E1 inhibits leukemia stem cells

September 25, 2017
Two drugs, already approved for safe use in people, may be able to improve therapy for chronic myeloid leukemia (CML), a blood cancer that affects myeloid cells, according to results from a University of Iowa study in mice.

MRI contrast agent locates and distinguishes aggressive from slow-growing breast cancer

September 25, 2017
A new magnetic resonance imaging (MRI) contrast agent being tested by researchers at Case Western Reserve University not only pinpoints breast cancers at early stages but differentiates between aggressive and slow-growing ...

Cancer vaccines need to target T cells that can persist in the long fight against cancer

September 25, 2017
Cancer vaccines may need to better target T cells that can hold up to the long fight against cancer, scientists report.

Lung cancer treatment could be having negative health effect on hearts

September 25, 2017
Radiotherapy treatment for lung cancer could have a negative effect on the health of your heart new research has found.

Alternative splicing, an important mechanism for cancer

September 22, 2017
Cancer, which is one of the leading causes of death worldwide, arises from the disruption of essential mechanisms of the normal cell life cycle, such as replication control, DNA repair and cell death. Thanks to the advances ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.