Post-polyp detection, CRC risk ID'd by colonoscopy factors

August 21, 2012
Post-polyp detection, CRC risk ID'd by colonoscopy factors
In the community setting, after colonoscopic polyp detection, colonoscopy-related factors such as incomplete polyp removal and lack of surveillance colonoscopies are more important than polyp characteristics in predicting subsequent colorectal cancer risk, according to a study published in the Aug. 21 issue of the Annals of Internal Medicine.

(HealthDay) -- In the community setting, after colonoscopic polyp detection, colonoscopy-related factors such as incomplete polyp removal and lack of surveillance colonoscopies are more important than polyp characteristics in predicting subsequent colorectal cancer (CRC) risk, according to a study published in the Aug. 21 issue of the Annals of Internal Medicine.

To examine the role of -related factors and polyp characteristics on the risk for CRC after detection of colonoscopic polyps, Hermann Brenner, M.D., M.P.H., of the German Cancer Research Center in Heidelberg, and colleagues used data from a previously published population-based, case-control study involving 3,148 case participants with CRC and 3,274 control patients.

The researchers identified 155 case participants and 260 with physician-validated polyp detection in the preceding 10 years. Among cases, characteristics that were significantly more common included: incomplete removal of all polyps (odds ratio [OR], 3.73); no surveillance colonoscopy within five years (OR, 2.96); and detection of three or more polyps (OR, 2.21). Overall, nearly twice as many CRC cases were due to colonoscopy-related rather than polyp-related characteristics (41.1 versus 21.7 percent).

"We found colonoscopy-related factors (in particular, lack of complete removal of all polyps and lack of surveillance colonoscopy within five years) to be more important predictors of CRC occurrence after colonoscopic detection of polyps (other than hyperplastic polyps) than polyp characteristics," the authors conclude.

Explore further: Study supports longer scope intervals post-polypectomy

More information: Full Text (subscription or payment may be required)

Related Stories

Study supports longer scope intervals post-polypectomy

July 24, 2012
(HealthDay) -- People who have had a colonoscopy during which a high-risk potentially cancerous polyp was removed may not need another colonoscopy for five years, German researchers report.

Colonoscopy screening markedly reduces colorectal cancer incidence and death

July 24, 2012
A study from researchers in Switzerland found that colonoscopy with polypectomy significantly reduces colorectal cancer incidence and colorectal cancer-related death in the general population. A total of 12 colorectal cancer ...

Physicians who play Mozart while performing colonoscopy may improve adenoma detection rate

October 31, 2011
Physicians who listen to Mozart while performing colonoscopy may increase their detection rates of precancerous polyps, according to the results of a new study unveiled today at the American College of Gastroenterology's ...

Recommended for you

Poliovirus therapy induces immune responses against cancer

September 20, 2017
An investigational therapy using modified poliovirus to attack cancer tumors appears to unleash the body's own capacity to fight malignancies by activating an inflammation process that counter's the ability of cancer cells ...

Scientists restore tumor-fighting structure to mutated breast cancer proteins

September 20, 2017
Scientists at the Virginia Tech Carilion Research Institute have successfully determined the full architecture of the breast cancer susceptibility protein (BRCA1) for the first time. This three-dimensional information provides ...

Brain cancer growth halted by absence of protein, study finds

September 20, 2017
The growth of certain aggressive brain tumors can be halted by cutting off their access to a signaling molecule produced by the brain's nerve cells, according to a new study by researchers at the Stanford University School ...

New clinical trial explores combining immunotherapy and radiation for sarcoma patients

September 20, 2017
University of Maryland School of Medicine researchers are investigating a new approach to treat high-risk soft-tissue sarcomas by combining two immunotherapy drugs with radiation therapy to stimulate the immune system to ...

Researchers identify new target, develop new drug for cancer therapies

September 20, 2017
Opening up a new pathway to fight cancer, researchers at the University of Pennsylvania have found a way to target an enzyme that is crucial to tumor growth while also blocking the mechanism that has made past attempts to ...

Targeted antibiotic use may help cure chronic myeloid leukaemia

September 19, 2017
The antibiotic tigecycline, when used in combination with current treatment, may hold the key to eradicating chronic myeloid leukaemia (CML) cells, according to new research.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.