White matter structural changes ID'd in children with T1DM

September 17, 2012
White matter structural changes ID'd in children with T1DM
Children with type 1 diabetes have significant structural differences in the white matter of their brain compared to healthy children, which correlates with hemoglobin A1c values, according to a study published online Sept. 10 in Diabetes Care.

(HealthDay)—Children with type 1 diabetes have significant structural differences in the white matter of their brain compared to healthy children, which correlates with hemoglobin A1c (HbA1c) values, according to a study published online Sept. 10 in Diabetes Care.

To examine clinical correlates of cognitive abilities and white matter microstructural changes in young children with diabetes, Tandy Aye, M.D., from the Stanford University School of Medicine in California, and colleagues used (DTI) scans and neurocognitive testing from 22 children (ages 3 to 10 years) with type 1 diabetes and 14 matched, healthy controls.

The researchers found that children with type 1 diabetes had significantly lower axial diffusivity (AD) values in the temporal and parietal lobe regions, compared with healthy controls. For fractional anisotropy and radial diffusivity (RD) there were no significant differences between the groups. There was a significant, positive correlation between time-weighted HbA1c and RD within the diabetes group. A higher, time-weighted HbA1c value also correlated with reduced overall intellectual functioning.

"Children with had significantly different white matter structure (as measured by AD) when compared with controls," the authors write. "In addition, white matter structural differences (as measured by RD) were significantly correlated with their HbA1c values."

Explore further: Study assesses glucose monitoring trends in tweens

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Study assesses glucose monitoring trends in tweens

April 12, 2012
(HealthDay) -- During the transition to adolescence, children with type 1 diabetes monitor their blood glucose less frequently, resulting in significant increases in HbA1c levels, according to research published online April ...

Sleep apnea severity linked to glycated hemoglobin levels

June 18, 2012
(HealthDay) -- For adults without diabetes, obstructive sleep apnea (OSA) severity is independently associated with impaired glucose metabolism, as measured by glycated hemoglobin (HbA1c) levels, according to a study published ...

Isomaltulose doesn't improve glycemic control in diabetes

April 13, 2012
(HealthDay) -- For patients with type 2 diabetes, substitution of sucrose with isomaltulose is not associated with improved glycemic control (measured by hemoglobin A1c [HbA1c] levels) at 12 weeks, according to a study published ...

White matter of abstinent alcoholics recovers over time

May 21, 2012
(HealthDay) -- Based on diffusion tensor imaging (DTI), the microstructural changes seen in the genu and body of the corpus callosum in recently detoxified alcohol-dependent patients are found to improve after one year of ...

HbA1c less than 6.5 percent is specific, not sensitive for T1DM

September 2, 2012
(HealthDay)—Using a glycated hemoglobin (HbA1c) threshold of ≥6.5 percent is a specific but not sensitive early indicator of type 1 diabetes (T1D) in high-risk children and young adults, according to a study published ...

Recommended for you

Genetic discovery may help better identify children at risk for type 1 diabetes

January 17, 2018
Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating ...

Thirty-year study shows women who breastfeed for six months or more reduce their diabetes risk

January 16, 2018
In a long-term national study, breastfeeding for six months or longer cuts the risk of developing type 2 diabetes nearly in half for women throughout their childbearing years, according to new Kaiser Permanente research published ...

Women who have gestational diabetes in pregnancy are at higher risk of future health issues

January 16, 2018
Women who have gestational diabetes mellitus (GDM) during pregnancy have a higher than usual risk of developing type 2 diabetes, hypertension, and ischemic heart disease in the future, according to new research led by the ...

Diabetes gene found that causes low and high blood sugar levels in the same family

January 15, 2018
A study of families with rare blood sugar conditions has revealed a new gene thought to be critical in the regulation of insulin, the key hormone in diabetes.

Discovery could lead to new therapies for diabetics

January 12, 2018
New research by MDI Biological Laboratory scientist Sandra Rieger, Ph.D., and her team has demonstrated that an enzyme she had previously identified as playing a role in peripheral neuropathy induced by cancer chemotherapy ...

Enzyme shown to regulate inflammation and metabolism in fat tissue

January 11, 2018
The human body has two primary kinds of fat—white fat, which stores excess calories and is associated with obesity, and brown fat, which burns calories in order to produce heat and has garnered interest as a potential means ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.