Got dry eyes? Measuring eyelid sensitivity may reflect the causes

October 3, 2012

A simple test of eyelid sensitivity may help vision professionals in evaluating one of the most common eye-related symptoms: dry eyes. A new study linking increased eyelid sensitivity to decreased function of the eyelid margins is presented in the article – "Lid Margins: Sensitivity, Staining, Meibomian Gland Dysfunction, and Symptoms", appearing in the October issue of Optometry and Vision Science, official journal of the American Academy of Optometry.

Isabelle Jabert, OD, MPH, PhD, FAAO, and colleagues of The University of New South Wales, Sydney, used a test called esthesiometry to measure the sensitivity of the eyelid margins—the very edge of the upper and lower eyelids. The test, easily performed in the optometrist's office, provides an accurate measure of the lid margin's sensitivity to touch. The included 27 healthy adults, average age 31 years.

The researchers then looked at how eyelid sensitivity was related to the function of some specialized structures of the eyelid margin. A special dye was also used to stain the innermost layer of the eyelid margin to assess the function of the meibomian glands, which secrete a specialized oil-like substance into the tear fluid.

The results showed some surprising differences between the upper and lower eyelids—including greater sensitivity of the lower-lid margin, compared to the upper lids.

And it was this increased lower lid sensitivity that was found to be related to hyperosmolarity of the tear film—that is, more concentrated tears. The finding suggests the potential for a new approach to clinically assessing tear osmolarity via lower lid sensitivity measures. Whereas past studies have shown a relationship between corneal sensitivity and osmolarity, none have addressed the possible lid sensitivity relationship. The ease with which the non-transparent lids can be accessed to measure sensitivity provides a potential clinical advantage over measuring sensitivity to touch on the cornea.

By comparison, the relationship between tear osmolarity and staining appears much more ambiguous.

The authors' results emphasize clear differences in staining and sensitivity between the upper and lower lids; for example the upper lids appear to be less sensitive and they stain less. Such findings may turn out to be important for interpretation of future studies of the dry eye condition.

Increased osmolarity and decreased meibomian gland function have both been linked to symptoms related to dry eye: one of the most common ocular complaints, especially in older people.

Recent research has led to increased understanding of the delicate structure and function of the lid margin, and their contribution to common eye-related symptoms. "There is renewed interest in the role of the eyelids in dry eye and meibomian gland dysfunction," comments Anthony Adams, OD, PhD, Editor-in-Chief of Optometry and .

The new results suggest that esthesiometry could provide optometrists with a simple test of lid margin , providing evidence of tear osmolarity. "This suggests a promising new tool for evaluating ocular health and effectiveness of treatment in dry eye disease and meibomian gland dysfunction," Dr Adams adds. The findings may provide "an expanded set of tools" for identifying problems leading to , and possibly for evaluating the effectiveness of new treatments.

Explore further: Common acne medication doubles risk of eye infection

More information: To read the article Lid Margins: Sensitivity, Staining, Meibomian Gland Dysfunction, and Symptoms", please visit journals.lww.com/optvissci/Ful … ng,_Meibomian.5.aspx

Related Stories

Common acne medication doubles risk of eye infection

May 23, 2012
Millions of teenagers suffer from acne, and they deal with the embarrassing skin blemishes by taking popular prescription medications such as Accutane or Roaccutane. Now, however, research from Tel Aviv University shows that ...

Caffeine use may offer relief for millions of dry eye sufferers

April 17, 2012
Researchers at the University of Tokyo's School of Medicine have shown for the first time that caffeine intake can significantly increase the eye's ability to produce tears, a finding that could improve treatment of dry eye ...

Recommended for you

Drinking hot tea every day linked to lower glaucoma risk

December 14, 2017
Drinking a cup of hot tea at least once a day may be linked to a significantly lower risk of developing the serious eye condition, glaucoma, finds a small study published online in the British Journal of Ophthalmology.

Newly published research provides new insight into how diabetes leads to retinopathy

December 7, 2017
An international team of scientists led by Professor Ingrid Fleming of Goethe University, Frankfurt, Germany, and including Professor Bruce Hammock of the University of California, Davis, provides new insight into the mechanism ...

Researchers use breakthrough technology to understand eclipse eye damage

December 7, 2017
In a first-of-its-kind study, Mount Sinai researchers are using adaptive optics (AO) to analyze retinal eye damage from the August solar eclipse on a cellular level. The research could help doctors develop a deeper understanding ...

Combating eye injuries with a reversible superglue seal

December 6, 2017
When a soldier sustains a traumatic eye injury on the battlefield, any delay in treatment may lead to permanent vision loss. With medical facilities potentially far away and no existing tools to prevent deterioration, medics ...

Trigger for most common form of vision loss discovered

November 27, 2017
In a major step forward in the battle against macular degeneration, the leading cause of vision loss among the elderly, researchers at the University of Virginia School of Medicine have discovered a critical trigger for the ...

Scientists engineer drug delivery device that treats glaucoma directly inside the eye

November 23, 2017
Glaucoma, which affects over 60 million people worldwide, can seem easy to treat: medicated eye drops can be used to ease the buildup of fluid in the eye that underlies the condition. If glaucoma is caught early, eye drops ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.