Morphology of bicuspid aortic valve influences outcomes

October 19, 2012
Morphology of bicuspid aortic valve influences outcomes
The morphology of bicuspid aortic valve malformations plays an important role in outcomes, according to a study published in the Nov. 1 issue of The American Journal of Cardiology.

(HealthDay)—The morphology of bicuspid aortic valve (BAV) malformations plays an important role in outcomes, according to a study published in the Nov. 1 issue of The American Journal of Cardiology.

Christiane Pees, M.D., and Ina Michel-Behnke, Ph.D., from the University Children's Hospital in Vienna, prospectively examined 48 with an isolated, native BAV and 48 matching subjects with tricuspid aortic valves for the morphology and size of the aortic valve, aortic root, sinotubular junction, and and their elasticity indexes.

The researchers found normal-size aortic dimensions in the tricuspid aortic valves, but in the BAVs, the ascending aorta and itself dilated with age and aortic elasticity deteriorated. The stiffness was significantly greater in the BAVs (4.43 ± 1.82 versus 3.43 ± 0.81 in the tricuspid aortic valves). There was a significant inverse decrease in the distensibility indexes in the BAVs (6.57 ± 2.83 versus 7.84 ± 2.04 cm² × dynes−1 × 10−6 and 53.5 ± 26.0 versus 64.3 ± 17.9 kPa−1 × 10−3). Even after correction for congenital valve dysfunction, the anteroposterior-oriented phenotype of BAVs showed significantly stiffer and less distensible elasticity, which was more frequent in the left-right-oriented phenotype.

"In conclusion, the morphology of the BAV seems to play a major role in the outcome of BAV disease, although the left-right phenotype is more prone to congenital valve dysfunction, the anteroposterior phenotype showed worse elasticity quality," the authors write.

Explore further: Study examines risk of aortic complications among patients with common congenital heart valve defect

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Study examines risk of aortic complications among patients with common congenital heart valve defect

September 13, 2011
While the incidence of the life-threatening condition of aortic dissection is significantly higher than in the general population, it remains low among patients with the congenital heart defect, bicuspid aortic valve; however, ...

Three SNPs linked to aortic stenosis in older adults

July 6, 2012
(HealthDay) -- Three single nucleotide polymorphisms (SNPs) are associated with aortic stenosis involving tricuspid aortic valves in older patients, according to a study published in the July 1 issue of The American Journal ...

Northwestern launches comprehensive program for patients with bicuspid aortic valve disease

July 3, 2012
Bicuspid aortic valve (BAV) disease is the most common congenital heart defect, occurring in approximately one to two percent of the population. The condition is present when the aortic valve, the valve that connects the ...

Recommended for you

Could aggressive blood pressure treatments lead to kidney damage?

July 18, 2017
Aggressive combination treatments for high blood pressure that are intended to protect the kidneys may actually be damaging the organs, new research from the University of Virginia School of Medicine suggests.

Quantifying effectiveness of treatment for irregular heartbeat

July 17, 2017
In a small proof-of-concept study, researchers at Johns Hopkins report a complex mathematical method to measure electrical communications within the heart can successfully predict the effectiveness of catheter ablation, the ...

Concerns over side effects of statins stopping stroke survivors taking medication

July 17, 2017
Negative media coverage of the side effects associated with taking statins, and patients' own experiences of taking the drugs, are among the reasons cited by stroke survivors and their carers for stopping taking potentially ...

Study discovers anticoagulant drugs are being prescribed against safety advice

July 17, 2017
A study by researchers at the University of Birmingham has shown that GPs are prescribing anticoagulants to patients with an irregular heartbeat against official safety advice.

Protein may protect against heart attack

July 14, 2017
DDK3 could be used as a new therapy to stop the build-up of fatty material inside the arteries

Heart study finds faulty link between biomarkers and clinical outcomes

July 14, 2017
Surrogate endpoints (biomarkers), which are routinely used in clinical research to test new drugs, should not be trusted as the ultimate measure to approve new health interventions in cardiovascular medicine, according to ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.