Study says VeriStrat predicts response but not survival benefit from erlotinib

October 15, 2012

A study, published in the November 2012 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, showed the plasma test VeriStrat can predict response but not survival benefit from erlotinib. The study was conducted on a subset of patients enrolled in the NCIC Clinical Trials Group, BR.21 phase III trial of erlotinib versus placebo in previously treated advanced non-small cell lung cancer patients.

VeriStrat is a commercially available serum-based or plasma-based test using matrix-assisted laser desorption ionization mass spectrometry methods. In this study, were used from 441 of 731 enrolled patients. VeriStrat testing was successful in 98.9 percent of samples (436), classifying patients as Good or Poor. For Good patients, the median survival was 10.5 months on versus 6.6 months on placebo. For Poor patients, the median survival was 4 month for patients on erlotinib and 3.1 months for patients on the placebo.

The authors confirmed that VeriStrat was predictive for response and also looked at whether or not VeriStrat is predictive for differential versus placebo. The interaction term comparing relative benefit in the two cohorts was not significant (p = 0.48), indicating that both the Good and Poor cohorts derived similar relative benefit from erlotinib. VeriStart was prognostic for both progression free and overall survival (i.e. in patients who did not receive erlotinib).

The authors conclude that VeriStrat is able to predict response, but neither progression nor overall survival to erlotinib and is a "prognostic biomarker in previously treated patients with advanced NSCLC. Further studies are required to define the clinical utility of VeriStrat and other blood-based biomarkers in defining the appropriate patient population for therapy with erlotinib and other EGFR-based therapies."

Explore further: EURTAC Phase III study: Erlotinib nearly doubles progression-free survival vs. chemotherapy

Related Stories

EURTAC Phase III study: Erlotinib nearly doubles progression-free survival vs. chemotherapy

July 5, 2011
In the first phase III study to include Western lung cancer patients, first-line treatment with erlotinib (Tarceva) nearly doubled progression-free survival compared with chemotherapy, according to research presented at the ...

Recommended for you

CAR-T immunotherapy may help blood cancer patients who don't respond to standard treatments

October 20, 2017
Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis is one of the first centers nationwide to offer a new immunotherapy that targets certain blood cancers. Newly approved ...

Researchers pinpoint causes for spike in breast cancer genetic testing

October 20, 2017
A sharp rise in the number of women seeking BRCA genetic testing to evaluate their risk of developing breast cancer was driven by multiple factors, including celebrity endorsement, according to researchers at the University ...

Study shows how nerves drive prostate cancer

October 19, 2017
In a study in today's issue of Science, researchers at Albert Einstein College of Medicine, part of Montefiore Medicine, report that certain nerves sustain prostate cancer growth by triggering a switch that causes tumor vessels ...

Gene circuit switches on inside cancer cells, triggers immune attack

October 19, 2017
Researchers at MIT have developed a synthetic gene circuit that triggers the body's immune system to attack cancers when it detects signs of the disease.

One to 10 mutations are needed to drive cancer, scientists find

October 19, 2017
For the first time, scientists have provided unbiased estimates of the number of mutations needed for cancers to develop, in a study of more than 7,500 tumours across 29 cancer types. Researchers from the Wellcome Trust Sanger ...

Researchers target undruggable cancers

October 19, 2017
A new approach to targeting key cancer-linked proteins, thought to be 'undruggable," has been discovered through an alliance between industry and academia.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.