Arthritis cartilage shows mitochondrial dysfunction

November 19, 2012
Arthritis cartilage shows mitochondrial dysfunction
Cartilage from osteoarthritis patients shows greater oxidative damage and mitochondrial dysfunction than healthy cartilage, which is associated with the downregulation of the superoxide dismutase 2 (SOD2) gene, according to a study published online Nov. 8 in Arthritis & Rheumatism.

(HealthDay)—Cartilage from osteoarthritis patients shows greater oxidative damage and mitochondrial dysfunction than healthy cartilage, which is associated with the downregulation of the superoxide dismutase 2 (SOD2) gene, according to a study published online Nov. 8 in Arthritis & Rheumatism.

To examine the impact of downregulation of SOD2 in osteoarthritis-affected mitochondria in the context of oxidative damage and in chondrocytes, Christos Gavriilidis, Ph.D., from Newcastle University in the United Kingdom, and colleagues compared lipid peroxidation, mitochondrial DNA (mtDNA) integrity, and mitochondrial respiration in from patients with osteoarthritis and from healthy patients with neck of femur fracture.

The researchers found that osteoarthritis cartilage had higher levels of lipid peroxidation, while osteoarthritis chondrocytes had lower spare respiratory capacity and higher proton leak, compared with cartilage from controls. There were no differences in the level of mitochondrial DNA damage between osteoarthritis and control chondrocytes, and osteoarthritis cartilage showed only very low levels of somatic, large-scale mtDNA rearrangements. Chondrocytes depleted of SOD2 showed similar characteristics to those of osteoarthritis cartilage in terms of having greater lipid peroxidation, lower spare respiratory capacity, and higher proton leak, but unlike osteoarthritis chondrocytes, they had significant increases in mtDNA strand breaks.

"These findings suggest that SOD2 depletion in chondrocytes leads to oxidative damage and mitochondrial dysfunction potentially contributing to ," Gavriilidis and colleagues conclude.

Explore further: Research team finds compound that can spur cartilage growth

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Research team finds compound that can spur cartilage growth

April 6, 2012
(Medical Xpress) -- A research team from drug maker Novartis has discovered a compound that spurs cartilage growth in mice. As they describe in their paper published in the journal Science, the team has found that when a ...

Scientists discover an epigenetic cause of osteoarthritis

July 6, 2012
In what could be a breakthrough in the practical application of epigenetic science, U.K. scientists used human tissue samples to discover that those with osteoarthritis have a signature epigenetic change (DNA methylation) ...

Recommended for you

Osteoarthritis could be treated as two diseases, scientists reveal

January 10, 2018
Scientists at The University of Manchester have discovered that most people with osteoarthritis can be subdivided into two distinct disease groups, with implications for diagnosis and drug development.

US arthritis prevalence is much higher than current estimates

November 27, 2017
New research indicates that the prevalence of arthritis in the United States has been substantially underestimated, especially among adults

Maintaining sufficient vitamin D levels may help to prevent rheumatoid arthritis

November 20, 2017
Maintaining sufficient vitamin D levels may help to prevent the onset of inflammatory diseases like rheumatoid arthritis, research led by the University of Birmingham has discovered.

Old World monkeys could be key to a new, powerful rheumatoid arthritis therapy

November 16, 2017
In the quest for a new and more effective treatment for rheumatoid arthritis, researchers from the Keck School of Medicine of USC looked to a primate that mostly roams the land in Asia, the Middle East and Africa. It was ...

Study lists foods for fighting rheumatoid arthritis symptoms and progression

November 8, 2017
A list of food items with proven beneficial effects on the progression and symptoms of rheumatoid arthritis is provided in a new study published today in Frontiers in Nutrition. The authors suggest incorporating these foods ...

Prototype equipment can detect rheumatoid arthritis

September 28, 2017
According to a first clinical study published in the scientific journal Photoacoustics, the University of Twente and various European partners have designed a device that shows the difference between healthy fingers and arthritic ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.