Bone marrow biopsy adds little to PET/CT staging of Hodgkin's

November 15, 2012

(HealthDay)—For patients with treatment-naive Hodgkin's lymphoma (HL) staged using [18F]fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT), routine bone marrow biopsy (BMB) has little or no therapeutic consequence, according to research published online Nov. 13 in the Journal of Clinical Oncology.

Tarec Chistoffer El-Galaly, M.D., of Aarhus University Hospital in Denmark, and colleagues conducted a involving 454 patients with newly diagnosed HL to determine whether BMB adds useful information to PET/CT staging.

Of the patients, 18 percent had focal skeletal PET/CT and 6 percent had positive BMB. Among patients assessed as having stage I to II disease by PET/CT staging, the researchers found that none were positive for BMB. Five patients assessed as being stage III before BMB were upstaged by BMB, but none of the patients were allocated to a different treatment based on the results of BMB. For identification of positive and negative BMBs, focal skeletal PET/CT lesions had a sensitivity of 85 percent and a specificity of 86 percent; the sensitivity and specificity for BMB results were 28 and 99 percent, respectively.

"To the best of our knowledge, this is the largest study to date examining the value of BMB in patients with HL who are undergoing PET/CT staging," the authors write. "The added diagnostic value from routine BMB was minimal, and positive BMB findings implied upstaging in only five patients from to stage IV disease of a total of 454 included patients."

Explore further: Life expectancy prolonged for esophageal cancer patients

More information: Abstract
Full Text (subscription or payment may be required)
Editorial

Related Stories

Life expectancy prolonged for esophageal cancer patients

June 4, 2012
For those with esophageal cancer, initial staging of the disease is of particular importance as it determines whether to opt for a curative treatment or palliative treatment. Research presented in the June issue of The Journal ...

PET more sensitive than CT for merkel cell carcinoma

May 15, 2012
(HealthDay) -- Fluorine-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography (PET) is significantly more sensitive and equally specific compared with traditional computed tomography (CT) imaging for evaluation of ...

Routine follow-up scans can detect head and neck cancer recurrences earlier

January 26, 2012
Routine use of positron emission tomography/computed tomography (PET/CT) scans in head and neck cancer patient follow-up can detect local recurrences before they become clinically apparent and may improve the outcome of subsequent ...

Low-dose whole-body CT finds disease missed on standard imaging for patients with multiple myeloma

May 2, 2012
Low dose whole body CT is nearly four times better than radiographic skeletal survey, the standard of care in the U.S., for determining the extent of disease in patients with multiple myeloma, a new study shows.

Recommended for you

How cancer metastasis happens: Researchers reveal a key mechanism

January 18, 2018
Cancer metastasis, the migration of cells from a primary tumor to form distant tumors in the body, can be triggered by a chronic leakage of DNA within tumor cells, according to a team led by Weill Cornell Medicine and Memorial ...

Modular gene enhancer promotes leukemia and regulates effectiveness of chemotherapy

January 18, 2018
Every day, billions of new blood cells are generated in the bone marrow. The gene Myc is known to play an important role in this process, and is also known to play a role in cancer. Scientists from the German Cancer Research ...

These foods may up your odds for colon cancer

January 18, 2018
(HealthDay)—Chowing down on red meat, white bread and sugar-laden drinks might increase your long-term risk of colon cancer, a new study suggests.

The pill lowers ovarian cancer risk, even for smokers

January 18, 2018
(HealthDay)—It's known that use of the birth control pill is tied to lower odds for ovarian cancer, but new research shows the benefit extends to smokers or women who are obese.

Researchers develop swallowable test to detect pre-cancerous Barrett's esophagus

January 17, 2018
Investigators at Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center have developed a simple, swallowable test for early detection of Barrett's esophagus that offers promise ...

Scientists zoom in to watch DNA code being read

January 17, 2018
Scientists have unveiled incredible images of how the DNA code is read and interpreted—revealing new detail about one of the fundamental processes of life.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.