Fat gene variants linked to middle age memory decline

November 8, 2012
Fat gene variants linked to middle age memory decline
For white middle-aged adults, there may be an association between variants in a gene associated with fat mass and obesity (FTO) and memory decline, according to research published online Nov. 7 in Neurology.

(HealthDay)—For white middle-aged adults, there may be an association between variants in a gene associated with fat mass and obesity (FTO) and memory decline, according to research published online Nov. 7 in Neurology.

Jan Bressler, Ph.D., from the University of Texas Health Science Center at Houston, and colleagues analyzed data from 15,792 individuals aged 45 to 64 years at baseline (1986 to 1989) participating in the Atherosclerosis Risk in Communities study. General linear models were used to assess the association between the six-year change in scores on three neuropsychological tests and FTO genotype.

The researchers found that, among 8,364 white and 2,083 African-American men and women with no clinical history of stroke, there was a significantly greater mean change in performance on the Delayed Word Recall Test which was associated with two of four FTO single nucleotide polymorphisms examined. This association was seen in whites but not in African-Americans and was independent of potential confounding variables, including age, gender, education, diabetes, hypertension, and .

"Further studies will be needed to clarify the and through which variants in FTO can increase susceptibility to decline in verbal memory detectable in middle-aged, community-dwelling adults," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Explore further: Physical activity reduces the effect of the 'obesity gene'

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Physical activity reduces the effect of the 'obesity gene'

November 1, 2011
The genetic predisposition to obesity due to the 'fat mass and obesity associated' (FTO) gene can be substantially reduced by living a physically active lifestyle according to new research by a large international collaboration, ...

Recommended for you

Recording a thought's fleeting trip through the brain

January 17, 2018
University of California, Berkeley neuroscientists have tracked the progress of a thought through the brain, showing clearly how the prefrontal cortex at the front of the brain coordinates activity to help us act in response ...

Midbrain 'start neurons' control whether we walk or run

January 17, 2018
Locomotion comprises the most fundamental movements we perform. It is a complex sequence from initiating the first step, to stopping when we reach our goal. At the same time, locomotion is executed at different speeds to ...

Brain zaps may help curb tics of Tourette syndrome

January 16, 2018
Electric zaps can help rewire the brains of Tourette syndrome patients, effectively reducing their uncontrollable vocal and motor tics, a new study shows.

A 'touching sight': How babies' brains process touch builds foundations for learning

January 16, 2018
Touch is the first of the five senses to develop, yet scientists know far less about the baby's brain response to touch than to, say, the sight of mom's face, or the sound of her voice.

Researchers identify protein involved in cocaine addiction

January 16, 2018
Mount Sinai researchers have identified a protein produced by the immune system—granulocyte-colony stimulating factor (G-CSF)—that could be responsible for the development of cocaine addiction.

Neuroscientists suggest a model for how we gain volitional control of what we hold in our minds

January 16, 2018
Working memory is a sort of "mental sketchpad" that allows you to accomplish everyday tasks such as calling in your hungry family's takeout order and finding the bathroom you were just told "will be the third door on the ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.