Sweat glands play major role in healing human wounds, research shows

Sweat glands play major role in healing human wounds, research shows
Credit: University of Michigan Health System

Turns out the same glands that make you sweat are responsible for another job vital to your health: they help heal wounds.

Human skin is rich with millions of eccrine sweat glands that help your body cool down after a trip to the gym or on a warm day. These same glands, new University of Michigan Health System research shows, also happen to play a key role in providing cells for recovering – such as scrapes, burns and ulcers.

The findings were released online ahead of print in the .

" – including those caused by diabetes or bed sores – and other non- remain a tremendous burden on health services and communities around the world," says lead author Laure Rittié, Ph.D., research assistant professor of dermatology at the University of Michigan Medical School.

"Treating chronic wounds costs tens of billions of dollars annually in the United States alone, and this price tag just keeps rising. Something isn't working."

Now, U-M researchers believe they have discovered one of the body's most powerful secret weapons in healing.

"By identifying a key process of wound closure, we can examine drug therapies with a new target in mind: sweat glands, which are very under-studied," Rittié says. "We're hoping this will stimulate research in a promising, new direction."

Previous understanding of was that new skin cells originate from hair follicles and from intact skin at the edge of the wound. The U-M findings demonstrate that cells arise from beneath the wound, and suggest that human eccrine sweat glands also store an important reservoir of that can quickly be recruited to aid wound healing.

"It may be surprising that it's taken until now to discover the sweat glands' vital role in wound repair," Rittié says. "But there's a good reason why these specific glands are under-studied – eccrine sweat glands are unique to humans and absent in the body skin of laboratory animals that are commonly used for wound healing research.

"We have discovered that humans heal their skin in a very unique way, different from other mammals," Rittié adds. "The regenerative potential of sweat glands has been one of our body's best-kept secrets. Our findings certainly advance our understanding of the normal healing process and will hopefully pave the way for designing better, targeted therapies."


Explore further

Artificial skin system can heal wounds

More information: dx.doi.org/10.1016/j.ajpath.2012.09.019
Journal information: American Journal of Pathology

Citation: Sweat glands play major role in healing human wounds, research shows (2012, November 20) retrieved 3 December 2021 from https://medicalxpress.com/news/2012-11-glands-major-role-human-wounds.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors