HIV-1 vaccine development: Pinning down a moving target

November 12, 2012

HIV-1 is a genetically diverse collection of viruses, making it a moving target in vaccine development.

In a study published in the , researchers led by Brad Jones at the University of Toronto in investigated the feasibility of eliminating HIV-infected cells by targeting cellular immune responses against a human endogenous retrovirus (HERV).

HERVs are the DNA remnants of ancient infectious retroviruses that became part of the germ line cells of our ancestors.

Jones and colleagues found that stimulated the expression of HERV proteins, effectively tagging HIV-infected cells.

targeted to these proteins specifically eliminated cells infected with several different strains of HIV in vitro. This study suggests that HERV-targeted immune responses should be considered in the development of HIV vaccines.

Explore further: Research illuminating long-term non-progression suggests novel vaccination strategy for HIV

More information: HERV-K-targeted T-cells eliminate diverse HIV-1/2 and SIV primary isolates, Journal of Clinical Investigation, 2012.

Related Stories

Research illuminating long-term non-progression suggests novel vaccination strategy for HIV

July 18, 2011
A major problem researchers have faced in attempting to develop a vaccine for HIV is that the virus mutates incredibly quickly, which means that its antigens—the target molecules of a vaccine—are moving targets. ...

Researchers discuss challenges to developing broadly protective HIV vaccines

September 7, 2011
The human body can produce powerful antibodies that shield cells in the laboratory against infection by an array of HIV strains. In people, however, recent research shows that these broadly neutralizing antibodies are not ...

Recommended for you

Scientists divulge latest in HIV prevention

July 25, 2017
A far cry from the 1990s "ABC" campaign promoting abstinence and monogamy as HIV protection, scientists reported on new approaches Tuesday allowing people to have all the safe sex they want.

Girl's HIV infection seems under control without AIDS drugs

July 24, 2017
A South African girl born with the AIDS virus has kept her infection suppressed for more than eight years after stopping anti-HIV medicines—more evidence that early treatment can occasionally cause a long remission that, ...

Meds by monthly injection might revolutionize HIV care (Update)

July 24, 2017
Getting a shot of medication to control HIV every month or two instead of having to take pills every day could transform the way the virus is kept at bay.

Candidate AIDS vaccine passes early test

July 24, 2017
The three-decade-old quest for an AIDS vaccine received a shot of hope Monday when developers announced that a prototype triggered the immune system in an early phase of human trials.

Paris spotlight on latest in AIDS science

July 21, 2017
Some 6,000 HIV experts gather in Paris from Sunday to report advances in AIDS science as fading hopes of finding a cure push research into new fields.

Scientists elicit broadly neutralizing antibodies to HIV in calves

July 20, 2017
Scientists supported by the National Institutes of Health have achieved a significant step forward, eliciting broadly neutralizing antibodies (bNAbs) to HIV by immunizing calves. The findings offer insights for HIV vaccine ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.