Statin use at cancer diagnosis linked to lower mortality

November 8, 2012
Statin use at cancer diagnosis linked to lower mortality
For patients with cancer, statin use prior to diagnosis correlates with reduced all-cause and cancer-related mortality, according to a study published in the Nov. 8 issue of the New England Journal of Medicine.

(HealthDay)—For patients with cancer, statin use prior to diagnosis correlates with reduced all-cause and cancer-related mortality, according to a study published in the Nov. 8 issue of the New England Journal of Medicine.

In an effort to examine whether statin use initiated before reduced cancer-related mortality, Sune F. Nielsen, Ph.D., from Copenhagen University Hospital in Denmark, and colleagues evaluated mortality among patients from the Danish population who had received a diagnosis of cancer between 1995 and 2007 and were followed up through December 2009. The cohort included 18,271 patients aged 40 or older who had used statins regularly before diagnosis, and 277,204 patients who had never used statins.

The researchers found that, compared with non-users, for statin users the multivariable-adjusted hazard ratios were significantly lower and were 0.85 each for death from any cause and death from cancer. The adjusted hazard ratios for all-cause mortality varied according to the defined daily dose of statin per day and were 0.82 for a dose of 0.01 to 0.75; 0.87 for a dose of 0.76 to 1.50; and 0.87 for a dose higher than 1.50. The corresponding hazard ratios for cancer-related mortality were 0.83, 0.87, and 0.87, respectively. For each of 13 there was reduced cancer-related mortality for statin users versus non-users.

"In conclusion, among patients with cancer, we observed an association between statin use at the time of diagnosis and a reduced risk of cancer-related mortality, with a reduction of up to 15 percent," the authors write. "Prospective evaluation of the hypothesis that statin use prolongs the survival of patients with cancer is needed."

One author disclosed to the .

Explore further: Post-SES implantation, statins prevent late revascularization

More information: Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Post-SES implantation, statins prevent late revascularization

May 12, 2012
(HealthDay) -- For patients who undergo sirolimus-eluting stent (SES) implantation, use of statin therapy is associated with a reduced risk of late target lesion revascularization (TLR), according to a study published in ...

Study finds no link between statins and cancer risk

July 25, 2011
(Medical Xpress) -- A new study published in the Journal of the American College of Cardiology reports that, contrary to previous studies, the use of cholesterol reducing statin drugs does not increase the risk of patients ...

Statins may help prolong survival in NSCLC resection

October 22, 2012
Patients who have undergone resection for non-small cell lung cancer (NSCLC) may improve their overall survival and reduce the risk of recurrence by taking statins.

Statins prevent cancer in heart transplant recipients

May 20, 2012
Statins prevent cancer and reduce death from all causes in heart transplant recipients. The findings were independent of cholesterol levels.

Recommended for you

Could a green sponge hold cancer-fighting secrets?

July 27, 2017
A small green sponge discovered in dark, icy waters of the Pacific off Alaska could be the first effective weapon against pancreatic cancer, researchers said on Wednesday.

Stem cell therapy attacks cancer by targeting unique tissue stiffness

July 26, 2017
A stem cell-based method created by University of California, Irvine scientists can selectively target and kill cancerous tissue while preventing some of the toxic side effects of chemotherapy by treating the disease in a ...

Understanding cell segregation mechanisms that help prevent cancer spread

July 26, 2017
Scientists have uncovered how cells are kept in the right place as the body develops, which may shed light on what causes invasive cancer cells to migrate.

Study uncovers potential 'silver bullet' for preventing and treating colon cancer

July 26, 2017
In preclinical experiments, researchers at VCU Massey Cancer Center have uncovered a new way in which colon cancer develops, as well as a potential "silver bullet" for preventing and treating it. The findings may extend to ...

Compound shows promise in treating melanoma

July 26, 2017
While past attempts to treat melanoma failed to meet expectations, an international team of researchers are hopeful that a compound they tested on both mice and on human cells in a petri dish takes a positive step toward ...

Study may explain failure of retinoic acid trials against breast cancer

July 25, 2017
Estrogen-positive breast cancers are often treated with anti-estrogen therapies. But about half of these cancers contain a subpopulation of cells marked by the protein cytokeratin 5 (CK5), which resists treatment—and breast ...

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

dogbert
1 / 5 (1) Nov 09, 2012
Let us try to manufacture another bogus reason to continue to sell statins.

Billions of dollars are at stake.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.