Fetuin-A levels linked to cardiovascular disease risk

January 8, 2013
Fetuin-A levels linked to cardiovascular disease risk
In elderly individuals without type 2 diabetes, high levels of fetuin-A, a protein that inhibits arterial calcification and insulin action, is associated with a lower risk of cardiovascular disease, according to a study published online Dec. 18 in Diabetes Care.

(HealthDay)—In elderly individuals without type 2 diabetes, high levels of fetuin-A, a protein that inhibits arterial calcification and insulin action, is associated with a lower risk of cardiovascular disease, according to a study published online Dec. 18 in Diabetes Care.

Majken K. Jensen, Ph.D., from the Harvard School of Public Health in Boston, and colleagues measured serum fetuin-A levels in 1992 in 3,810 individuals 65 years and older (511 with ) who were free of cardiovascular disease. Participants were followed though June 2008 for incident cardiovascular disease.

During a median follow-up of 10.9 years, the researchers recorded a cardiovascular event in 1,456 individuals overall and in 248 of the individuals with type 2 diabetes. Higher fetuin-A levels were associated with a significantly lower risk of cardiovascular disease in the absence of type 2 diabetes (hazard ratio [HR], 0.93 per 0.1 g/L higher fetuin-A). For individuals with type 2 diabetes, higher fetuin-A levels were associated with a non-significant increase in . Higher fetuin-A levels were associated with a significantly lower risk of cardiovascular disease only in non-obese individuals (HR, 0.91) and in those with Homeostasis Model Assessment for Insulin Resistance below the median (HR, 0.87).

"In a population of older community-living persons, the association of fetuin-A concentrations with risk of incident cardiovascular disease is modified by and type 2 diabetes," Jensen and colleagues conclude.

Explore further: Diabetes associated with higher risk of cardiovascular problems in men

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Diabetes associated with higher risk of cardiovascular problems in men

March 25, 2012
According to a new study by researchers at Brigham and Women's Hospital (BWH), men with type 2 diabetes treated with insulin without a history of cardiovascular disease (CVD) were at higher risk for major cardiovascular events ...

Type 2 diabetes linked to higher risk of stroke and CV problems; metabolic syndrome isn't

June 13, 2011
Among patients who have had an ischemic stroke or transient ischemic attack (TIA), type 2 diabetes was associated with an increased risk of recurrent stroke or cardiovascular events, but metabolic syndrome was not, according ...

Depression found to increase risk of death in diabetes

June 1, 2012
(HealthDay) -- For patients with type 2 diabetes, depression is associated with an increased risk of all-cause mortality, regardless of previous cardiovascular disease, according to a study published online May 22 in Diabetes ...

Recommended for you

Genetic discovery may help better identify children at risk for type 1 diabetes

January 17, 2018
Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating ...

Women who have gestational diabetes in pregnancy are at higher risk of future health issues

January 16, 2018
Women who have gestational diabetes mellitus (GDM) during pregnancy have a higher than usual risk of developing type 2 diabetes, hypertension, and ischemic heart disease in the future, according to new research led by the ...

Diabetes gene found that causes low and high blood sugar levels in the same family

January 15, 2018
A study of families with rare blood sugar conditions has revealed a new gene thought to be critical in the regulation of insulin, the key hormone in diabetes.

Discovery could lead to new therapies for diabetics

January 12, 2018
New research by MDI Biological Laboratory scientist Sandra Rieger, Ph.D., and her team has demonstrated that an enzyme she had previously identified as playing a role in peripheral neuropathy induced by cancer chemotherapy ...

Enzyme shown to regulate inflammation and metabolism in fat tissue

January 11, 2018
The human body has two primary kinds of fat—white fat, which stores excess calories and is associated with obesity, and brown fat, which burns calories in order to produce heat and has garnered interest as a potential means ...

Big strides made in diabetes care

January 5, 2018
(HealthDay)—This past year was a busy, productive one for diabetes research and care.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.