AB blood type strong risk factor for venous blood clots

February 4, 2013, Canadian Medical Association Journal

The non-O ABO blood type is the most important risk factor for venous thromboembolism (blood clots in veins), making up 20% of attributable risk for the condition, according to a new study in CMAJ (Canadian Medical Association Journal).

This finding has implications for genetic screening for thrombophilia, a to abnormal blood clotting.

Danish researchers looked at data on 66 001 people who had been followed for 33 years from 1977 through 2010 to determine whether ABO blood type is associated with an increased risk of venous blood clots in the general population. They found that the risk increased when ABO blood type was combined with factor V Leiden R506Q or prothrombin G20210A, associated with an increased risk of venous thromboembolisms. This finding confirms the conclusion of other studies. The researchers also found an 11-fold increased risk of venous thromboembolism for people with the prothrombin G20210A mutation in double dose, something other smaller trials did not pick up.

"We found an additive effect of ABO blood type on risk of venous thromboembolism when combined with factor V Leiden R506Q and prothrombin G20210A; ABO blood type was the most important risk factor for venous thromboembolism in the general population.," writes Dr. Børge G. Nordestgaard, Herlev Hospital, Copenhagen University Hospital with coauthors. "This suggests that ABO blood type should be included in genetic screening for thrombophilia."

The study was large, followed participants over a long period and follow up was 100% complete for participants. Although the study cohort was genetically homogenous compared with populations with , the ABO blood type, factor V Leiden R506Q and prothrombin G20210A are found in all ethnicities.

Explore further: Risk of blood clots two-fold for women with polycystic ovary syndrome on combined pill

More information: www.cmaj.ca/lookup/doi/10.1503/cmaj.121636

Related Stories

Risk of blood clots two-fold for women with polycystic ovary syndrome on combined pill

December 3, 2012
Women with polycystic ovary syndrome (PCOS) who are taking combined oral contraceptives have a 2-fold risk of blood clots compared with women without the disorder who take contraceptives, states a study published in CMAJ ...

Risk of blood clots in veins hereditary

May 31, 2011
Venous thromboembolism (VTE) is the third most common type of cardiovascular disease after coronary heart disease and stroke. Researchers at the Centre for Primary Health Care Research in Malmo have mapped the significance ...

Major illness increases venous thrombosis risk

November 3, 2012
(HealthDay)—People with major illnesses, including liver or kidney disease, rheumatoid arthritis, multiple sclerosis, heart failure, hemorrhagic stroke, or arterial thrombosis, have an increased risk of venous thrombosis ...

New research suggests all primates shared common blood type ancestor

October 23, 2012
(Medical Xpress)—An international team of researchers has found evidence that suggests that the ABO blood types found in all primates developed in a shared common ancestor. In their paper published in the Proceedings of ...

Recommended for you

Study ends debate over role of steroids in treating septic shock

January 19, 2018
The results from the largest ever study of septic shock could improve treatment for critically ill patients and save health systems worldwide hundreds of millions of dollars each year.

New approach could help curtail hospitalizations due to influenza infection

January 18, 2018
More than 700,000 Americans were hospitalized due to illnesses associated with the seasonal flu during the 2014-15 flu season, according to federal estimates. A radical new approach to vaccine development at UCLA may help ...

Zika virus damages placenta, which may explain malformed babies

January 18, 2018
Though the Zika virus is widely known for a recent outbreak that caused children to be born with microencephaly, or having a small head, and other malformations, scientists have struggled to explain how the virus affects ...

Certain flu virus mutations may compensate for fitness costs of other mutations

January 18, 2018
Seasonal flu viruses continually undergo mutations that help them evade the human immune system, but some of these mutations can reduce a virus's potency. According to new research published in PLOS Pathogens, certain mutations ...

Study reveals how MRSA infection compromises lymphatic function

January 17, 2018
Infections of the skin or other soft tissues with the hard-to-treat MRSA (methicillin-resistant Staphylococcus aureus) bacteria appear to permanently compromise the lymphatic system, which is crucial to immune system function. ...

Fresh approach to tuberculosis vaccine offers better protection

January 17, 2018
A unique platform that resulted in a promising HIV vaccine has also led to a new, highly effective vaccine against tuberculosis that is moving toward testing in humans.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.