Vascular markers linked to cognitive decline in diabetes

April 18, 2013
Vascular markers linked to cognitive decline in diabetes
Stroke and subclinical markers of macrovascular disease are associated with cognitive decline in older adults with type 2 diabetes, according to a study published online April 11 in Diabetes Care.

(HealthDay)—Stroke and subclinical markers of macrovascular disease are associated with cognitive decline in older adults with type 2 diabetes, according to a study published online April 11 in Diabetes Care.

Insa Feinkohl, from the University of Edinburgh in the United Kingdom, and colleagues measured signs of macrovascular disease in 831 cognitively healthy older adults with type 2 diabetes. Subjects underwent seven at baseline and after four years. Lifetime cognitive change was estimated by adjustment for vocabulary.

The researchers found a significant association between measures of cognitive decline and stroke, N-terminal probrain natriuretic peptide, ankle brachial index, and carotid intima-media thickness. There was a significant association between stroke and increased estimated lifetime cognitive decline, as well as between subclinical markers and actual four-year decline. Adjusting for had little effect. There was no association found between measures of cognitive decline and non-stroke vascular events.

"Stroke and subclinical markers of and generalized atherosclerosis are associated with in older patients with type 2 diabetes," Feinkohl and colleagues conclude.

The study was funded in part by Pfizer.

Explore further: Accelerated cognitive decline seen with T2DM in middle age

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Accelerated cognitive decline seen with T2DM in middle age

January 21, 2013
(HealthDay)—Middle-aged patients with type 2 diabetes show accelerated cognitive decline in information processing speed and executive function, according to a study published online Dec. 28 in Diabetes Care.

Vitamin D not tied to subclinical atherosclerosis in T1DM

April 12, 2013
(HealthDay)—For individuals with type 1 diabetes, low concentrations of vitamin D metabolites are not associated with an increased risk of subclinical atherosclerosis, according to a study published online March 25 in Diabetes ...

Tests to predict heart problems may be more useful predictor of memory loss than dementia tests

April 1, 2013
Risk prediction tools that estimate future risk of heart disease and stroke may be more useful predictors of future decline in cognitive abilities, or memory and thinking, than a dementia risk score, according to a new study ...

Vascular changes linked to dementia

July 21, 2011
The same artery-clogging process (atherosclerosis) that causes heart disease can also result in age-related vascular cognitive impairments (VCI), according to a new American Heart Association/American Stroke Association scientific ...

Diabetes, poor glucose control associated with greater cognitive decline in older adults

June 18, 2012
Among well-functioning older adults without dementia, diabetes mellitus (DM) and poor glucose control among those with DM are associated with worse cognitive function and greater cognitive decline, according to a report published ...

Recommended for you

Genetic discovery may help better identify children at risk for type 1 diabetes

January 17, 2018
Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating ...

Women who have gestational diabetes in pregnancy are at higher risk of future health issues

January 16, 2018
Women who have gestational diabetes mellitus (GDM) during pregnancy have a higher than usual risk of developing type 2 diabetes, hypertension, and ischemic heart disease in the future, according to new research led by the ...

Diabetes gene found that causes low and high blood sugar levels in the same family

January 15, 2018
A study of families with rare blood sugar conditions has revealed a new gene thought to be critical in the regulation of insulin, the key hormone in diabetes.

Discovery could lead to new therapies for diabetics

January 12, 2018
New research by MDI Biological Laboratory scientist Sandra Rieger, Ph.D., and her team has demonstrated that an enzyme she had previously identified as playing a role in peripheral neuropathy induced by cancer chemotherapy ...

Enzyme shown to regulate inflammation and metabolism in fat tissue

January 11, 2018
The human body has two primary kinds of fat—white fat, which stores excess calories and is associated with obesity, and brown fat, which burns calories in order to produce heat and has garnered interest as a potential means ...

Big strides made in diabetes care

January 5, 2018
(HealthDay)—This past year was a busy, productive one for diabetes research and care.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.