Shift in lung allocation score alters transplant survival

May 8, 2013
Shift in lung allocation score alters transplant survival
An acute increase in lung allocation score before transplantation is associated with worse post-transplant survival, according to a study published in the May 7 issue of the Annals of Internal Medicine.

(HealthDay)—An acute increase in lung allocation score (LAS) before transplantation is associated with worse post-transplant survival, according to a study published in the May 7 issue of the Annals of Internal Medicine.

Wayne M. Tsuang, M.D., from the Duke University Medical Center in Durham, N.C., and colleagues retrospectively analyzed data from 5,749 adult lung transplant recipients listed for at least 30 days between May 4, 2005 (LAS implementation) and Dec. 31, 2010, in the United Network for Organ Sharing registry. An LAS change (LASΔ) of >5 units between the 30 days before and the time of transplantation was the definition for an acute increase in LAS.

The researchers found that 702 patients (12.2 percent) experienced an LASΔ of >5. After adjusting for LAS at transplantation (LAS-T) and other clinical covariates, these patients had significantly worse post-transplant survival (hazard ratio, 1.31). The findings regarding LASΔ of >5 were independent of the LAS-T, underlying , center volume, or donor characteristics.

"The LAS has proven to be a clinically useful means to allocate organs within the United States and has reduced wait-list deaths without adversely affecting post-transplant survival," the authors write. "Further analysis of the patterns of change in LAS and its effect on post-transplant survival could help refine estimations of net benefit of and improve organ allocation."

One author disclosed to ImmuneWorks.

Explore further: Lung transplant system often skips over those most in need

More information: Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Lung transplant system often skips over those most in need

January 31, 2012
The current system for allocating donated lungs based on proximity and not on need appears to decrease the potential benefits of lung transplantation and increase the number of patients who die waiting, researchers said at ...

Good transplant outcomes in hypertrophic cardiomyopathy

August 17, 2012
(HealthDay) -- Post-heart transplant survival does not differ significantly between patients with hypertrophic cardiomyopathy (HC) and those with other types of heart disease, according to a study published in the Aug. 15 ...

Policy of including smokers in donor pool improves survival rates for patients on lung transplant waiting lists

May 28, 2012
New research shows that lung transplant patients who receive the lungs of smokers have a better overall chance of survival than those who remain on waiting lists, despite the fact that they tend to survive for a shorter period ...

Recommended for you

Drug may help surgical patients stop opioids sooner

December 13, 2017
(HealthDay)—Opioid painkillers after surgery can be the first step toward addiction for some patients. But a common drug might cut the amount of narcotics that patients need, a new study finds.

Children best placed to explain facts of surgery to patients, say experts

December 13, 2017
Getting children to design patient information leaflets may improve patient understanding before they have surgery, finds an article in the Christmas issue of The BMJ.

Burn victim saved by skin grafts from identical twin (Update)

November 23, 2017
A man doomed to die after suffering burns across 95 percent of his body was saved by skin transplants from his identical twin in a world-first operation, French doctors said Thursday.

Is a common shoulder surgery useless?

November 21, 2017
(HealthDay)—New research casts doubt on the true effectiveness of a common type of surgery used to ease shoulder pain.

Study shows electric bandages can fight biofilm infection, antimicrobial resistance

November 6, 2017
Researchers at The Ohio State University Wexner Medical Center have shown - for the first time - that special bandages using weak electric fields to disrupt bacterial biofilm infection can prevent infections, combat antibiotic ...

Obesity increases incidence, severity, costs of knee dislocations

November 3, 2017
A new study of more than 19,000 knee dislocation cases in the U.S. between 2000 and 2012 provides a painful indication of how the nation's obesity epidemic is changing the risk, severity and cost of a traumatic injury.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.