Racial discrepancy in oncologic outcomes for low-risk PCa

Racial discrepancy in oncologic outcomes for low-risk PCa
Among men with very-low-risk prostate cancer who meet criteria for active surveillance but undergo radical prostatectomy, African-American race is associated with poorer outcomes, with higher rates of disease upgrading and adverse pathology, according to a study published online June 17 in the Journal of Clinical Oncology.

(HealthDay)—Among men with very-low-risk prostate cancer (PCa) who meet criteria for active surveillance but undergo radical prostatectomy, African-American race is associated with poorer outcomes, with higher rates of disease upgrading and adverse pathology, according to a study published online June 17 in the Journal of Clinical Oncology.

To examine whether race-based exist among men with very-low-risk PCa who undergo , Debasish Sundi, M.D., from Johns Hopkins University in Baltimore, and colleagues studied 1,801 men (256 African-American, 1,473 white, and 72 others) who met National Comprehensive Cancer Network criteria for very low-risk PCa. Comparisons were made by racial group with regards to presenting characteristics, pathologic data, and .

The researchers found that more adverse pathologic features at prostatectomy and poorer oncologic outcomes were seen for African-American men with very-low-risk PCa. For African-American men, there was an increased likelihood of experiencing disease upgrading at prostatectomy (27.3 versus 14.4 percent; P < 0.001); positive surgical margins (9.8 versus 5.9 percent; P = 0.02); and higher Cancer of the Prostate Risk Assessment Post-Surgical scoring system scores. African-American race was an independent predictor of adverse pathologic features and pathologic upgrading (odds ratio, 3.23 and 2.26, respectively), on multivariate analysis.

"African-American men with very-low-risk PCa should be counseled about increased oncologic risk when deciding among their disease management options," the authors write.


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Citation: Racial discrepancy in oncologic outcomes for low-risk PCa (2013, June 18) retrieved 23 October 2019 from https://medicalxpress.com/news/2013-06-racial-discrepancy-oncologic-outcomes-low-risk.html
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