Scientists successfully generate 'artificial bones' from umbilical cord stem cells

July 18, 2013

Scientists in Granada, Spain, have patented a new biomaterial that facilitates generating bone tissue—artificial bones in other words—from umbilical cord stem cells . The material, consisting of an activated carbon cloth support for cells that differentiate giving rise to a product that can promote bone growth, has recently been presented at a press conference at the Biomedical Research Centre, Granada.

Although the method has not yet been applied with 'in vivo' models, laboratory results are highly promising. In the future, they could help manufacture medicines for the repair of bone or osteochondrial, tumour or traumatic lesions and to replace lost cartilage in limbs. After obtaining artificial bones in the laboratory, the researchers' next step is to implant this biomaterial in experimental animal models—like rats or rabbits—to see if it can regenerate bone in them.

The scientists, from the Biomedical Research Centre and the Faculties of Sciences of the Universities of Granada and Jaén, and the Spanish National Research Council Institute of Parasitology and Biomedicine "López Neyra", have made this important scientific breakthrough after years of research in cell biology, and materials studies.

Ground-breaking, worldwide scientific advance

As the authors of the patent explain, no alternative materials are currently available on the market, nor have any been described in the literature. Precedents exist in the development of materials that fulfil the basic function of stimulating cell differentiation but a biologically complex material similar to has never before been produced "ex vivo".

What's more, the method of developed in Granada uses a three-dimensional support and facilitates obtaining cell types implicated in in cell culture conditions not requiring additional differentiation factors or factors that differ from those present in the cell culture serum. In other words, thanks to this invention, a biomaterial consisting of supported on activated carbon cloth and capable of generating a product in which osteochondrial and mineralized extracellular organic matrix lineage cells exist, can be obtained.

The patent developed in Granada could have numerous applications in stem cell use in regenerative medicine, as well as in treating bone tissue and cartilage lesion problems.

Following this important scientific finding, the researchers are confident of obtaining the finance needed to be able to continue this work and achieve the ultimate objective of their invention: to regenerate bones by implanting in patients with pathologies affecting the osseous system.

Explore further: Fat in organs and blood may increase risk of osteoporosis

Related Stories

Fat in organs and blood may increase risk of osteoporosis

July 16, 2013
Excess fat around the belly has recently been identified as a risk factor for bone loss. Now, a new study has determined that excess liver and muscle fat also may be detrimental to bone.

Researchers use synthetic silicate to stimulate stem cells into bone cells

May 14, 2013
In new research published online May 13, 2013 in Advanced Materials, researchers from Brigham and Women's Hospital (BWH) are the first to report that synthetic silicate nanoplatelets (also known as layered clay) can induce ...

Study coaxes clays to make human bone

May 31, 2013
Weak bones, broken bones, damaged bones, arthritic bones. Whether damaged by injury, disease or age, your body can't create new bone, but maybe science can. Researchers at North Dakota State University, Fargo, are making ...

New method for creating long-lived stem cells used for bone replacement

December 4, 2012
Human mesenchymal stem cells (hMSCs) can develop into bone cells and are useful for tissue engineering and regeneration. However, when grown in the laboratory they quickly lose their ability to continue dividing and they ...

Recommended for you

Scientists find RNA with special role in nerve healing process

August 22, 2017
Scientists may have identified a new opening to intervene in the process of healing peripheral nerve damage with the discovery that an "anti-sense" RNA (AS-RNA) is expressed when nerves are injured. Their experiments in mice ...

Mouse model of human immune system inadequate for stem cell studies

August 22, 2017
A type of mouse widely used to assess how the human immune system responds to transplanted stem cells does not reflect what is likely to occur in patients, according to a study by researchers at the Stanford University School ...

Researchers offer new targets for drugs against fatty liver disease and liver cancer

August 22, 2017
There may no silver bullet for treating liver cancer or fatty liver disease, but knowing the right targets will help scientists develop the most effective treatments. Researchers in Sweden have just identified a number of ...

Make way for hemoglobin

August 18, 2017
Every cell in the body, whether skin or muscle or brain, starts out as a generic cell that acquires its unique characteristics after undergoing a process of specialization. Nowhere is this process more dramatic than it is ...

Bio-inspired materials give boost to regenerative medicine

August 18, 2017
What if one day, we could teach our bodies to self-heal like a lizard's tail, and make severe injury or disease no more threatening than a paper cut?

Are stem cells the link between bacteria and cancer?

August 17, 2017
Gastric carcinoma is one of the most common causes of cancer-related deaths, primarily because most patients present at an advanced stage of the disease. The main cause of this cancer is the bacterium Helicobacter pylori, ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.