First-trimester biomarker may help identify early GDM risk

August 9, 2013
First-trimester biomarker may help identify early GDM risk
Glycosylated fibronectin may be able to identify pregnant women during the first trimester at risk for developing gestational diabetes mellitus, according to a study published online Aug. 5 in Obstetrics & Gynecology.

(HealthDay)—Glycosylated fibronectin may be able to identify pregnant women during the first trimester at risk for developing gestational diabetes mellitus (GDM), according to a study published online Aug. 5 in Obstetrics & Gynecology.

Juha P. Rasanen, M.D., Ph.D., from the Oregon Health and Science University in Portland, and colleagues measured serum concentrations of glycosylated (Sambucus nigra lectin-reactive) fibronectin, adiponectin, sex hormone-binding globulin, placental lactogen, and high-sensitivity C-reactive protein (CRP) in 90 pregnant women (who subsequently developed GDM) at 5 to 13 weeks of gestation and in 92 control participants.

The researchers observed a significant association between GDM and serum concentrations of glycosylated fibronectin, adiponectin, high-sensitivity CRP, and placental lactogen. Glycosylated fibronectin remained independently associated with GDM after adjusting for maternal factors and other markers. Above a threshold of 120 mg/L, glycosylated fibronectin levels correctly identified 57 GDM case group participants, with a positive predictive value of 63 percent and a negative predictive value of 95 percent, at a population prevalence of 12 percent.

"First-trimester glycosylated is a potential pregnancy-specific biomarker for early identification of women at risk for GDM," the authors write.

Several authors disclosed financial ties to DiabetOmics, which funded the study.

Explore further: Low adiponectin in first trimester linked to GDM

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Low adiponectin in first trimester linked to GDM

February 1, 2013
(HealthDay)—Low adiponectin levels during the first trimester of pregnancy correlate with a higher level of insulin resistance and an increased risk of developing gestational diabetes mellitus (GDM), according to research ...

4.4 mmol/L is optimal fasting glucose cutoff for GDM screening

April 16, 2013
(HealthDay)—A fasting plasma glucose value of 4.4 mmol/L is the optimal cut point for determining which pregnant Chinese women need a 75-g 2-h oral glucose tolerance test offered at 24 to 28 weeks' gestation, according ...

Rates of gestational diabetes mellitus vary by state

June 18, 2013
(HealthDay)—Obesity, age, race/ethnicity, hospital characteristics, and insurance type may contribute to the variability in rates of gestational diabetes mellitus (GDM) between states, according to research published in ...

Gestational diabetes ups costs of maternity care by one-third

January 22, 2013
(HealthDay)—Women with gestational diabetes mellitus (GDM) are significantly more likely to receive an emergency cesarean section, have their infant admitted to a neonatal care unit, and incur significantly higher maternity ...

High fruit consumption not linked to gestational diabetes

March 29, 2012
(HealthDay) -- Higher consumption of whole fruits prior to pregnancy is not associated with increased risk of gestational diabetes mellitus (GDM), and the association between fruit juice consumption and GDM appears to be ...

BMI thresholds for gestational diabetes differ by race

June 1, 2012
(HealthDay) -- There is considerable racial/ethnic variation in the prevalence of gestational diabetes mellitus (GDM) by body mass index (BMI), according to a study published online May 22 in Diabetes Care.

Recommended for you

New study finds 'baby brain' is real, but the cause remains mysterious

January 15, 2018
So-called "baby brain" refers to increased forgetfulness, inattention, and mental "fogginess" reported by four out of five pregnant women. These changes in brain function during pregnancy have long been recognised in midwifery ...

Sleep quality improves with help of incontinence drug

January 12, 2018
A drug used to curtail episodes of urinary incontinence in women also improves quality of sleep, a researcher at the Stanford University School of Medicine reports.

Frozen embryos result in just as many live births in IVF

January 10, 2018
Freezing and subsequent transfer of embryos gives infertile couples just as much of a chance of having a child as using fresh embryos for in vitro fertilization (IVF), research from Ho Chi Minh City, Vietnam, and Adelaide, ...

Study suggests air pollution breathed in the months before and after conception increases chance of birth defects

January 8, 2018
A team of researchers with the University of Cincinnati and Cincinnati Children's Hospital has found evidence that indicates that pre-and post-pregnant women living in an area with air pollution are at an increased risk of ...

Taking paracetamol during pregnancy may reduce fertility of daughters

January 5, 2018
Taking paracetamol during pregnancy may impair the future fertility of female offspring, according to a review published in Endocrine Connections. The article reviews three separate rodent studies that all report altered ...

Advanced MRI can detect placental perfusion abnormalities in pregnancies complicated by fetal CHD

January 5, 2018
In pregnancies complicated by fetal congenital heart disease (CHD), global placental perfusion was significantly decreased and regional variation of placental perfusion significantly increased as pregnancies progressed, findings ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.