A healthy side effect of diabetes drug

September 23, 2013
Dr Dear said the drugs potential was important, as Type 2 diabetics often had poor cardiovascular health. Credit: iStock

(Medical Xpress)—New research has shown the promising potential of a glucose-regulating drug to improve the condition of arteries for diabetes sufferers, possibly protecting them against heart attack or stroke.

Dr Anthony Dear and Professor Richard Simpson from Monash University's Eastern Clinical Research Unit are leading a research team, who for several years have been investigating the beneficial side effect of the a new glucose-regulating medication.

A pre-clinical study, published in the journal Diabetes and Vascular Disease Research, demonstrated potentially beneficial effects of the drug in improving or stabilising diabetic vascular disease.

Dr Dear said the drug's potential was important, as Type 2 diabetics often had poor cardiovascular health.

"As the of diabetes escalates, this drug has the potential to offer tremendous help to millions of diabetics worldwide," Dr Dear said.

"Pre-clinical studies suggest the drug may improve in Type 2 diabetics. We think it may have the potential to reduce heart attacks and strokes in those diabetics whose cardiovascular systems are damaged due to the disease.

"Lots of drugs lower blood sugar but they don't necessarily protect blood vessels."

Dr Dear said the drug was derived from the natural gut hormone, Glucagon-Like Peptide-1 (GLP-1).

"It effectively lowers by stimulating in the body. It is a derivative of a naturally-occurring substance which appears to have receptors for it on the surface of in addition to the pancreas, suggesting it may also have an effect on ," Dr Dear said.

"We think it may also 'smooth' the surface of and make them less sticky and prone to develop 'blockages' - a condition frequently seen in Type 2 diabetics. This would mean that blockages, often contributing to the cause of heart attacks and strokes, would be less likely to form."

Dr Dear said the drug might have the extra potential to improve some of the challenges experienced by diabetics, including weight loss.

"One of the effects of the drug, and natural hormone from which the drug is derived, is to cause weight loss," Dr Dear said.

"Its benefits outside of lowering blood-sugar levels are conducive to problems that diabetics may have, such as being overweight or accelerated blood vessel disease."

The research is being conducted by the Eastern Clinical Research Unit, Translational Research Division at Monash in collaboration with the University's Department of Pharmacology.

The World Health Organisation reports that more that more than 347 million people worldwide live with diabetes and around 90 per cent of these cases are Type 2.

Explore further: Gout drug shown to benefit diabetes patients at risk of heart disease

More information: dvr.sagepub.com/content/early/ … 64113481817.full.pdf

Related Stories

Gout drug shown to benefit diabetes patients at risk of heart disease

August 29, 2013
New research carried out at the University of Dundee has led to the possibility of using an old drug to help prevent the biggest cause of death in Type II diabetes patients.

Short-term blood sugar control in patients with diabetes has limited effect on risk of cardiovascular problems

September 3, 2013
(Medical Xpress)—An international study has shown that short-term blood sugar control in patients with diabetes has a limited effect on their risk of cardiovascular problems, such as heart disease and stroke.

Cardiovascular risk in type 2 diabetics with dangerously low blood sugar levels

July 30, 2013
Type 2 diabetics who have severe hypoglycaemia are at higher risk of cardiovascular disease, a paper published today in BMJ suggests.

Diabetes drug may reduce brain damage after stroke

December 3, 2012
In a study in mice, scientists at Karolinska Institutet in Sweden have discovered a new potential therapy that may reduce brain damage following stroke in type 2 diabetic patients. The suggested drug is already approved for ...

Pain reliever lowers blood sugar in type 2 diabetics, study says

July 1, 2013
(HealthDay)— An aspirin-like drug appears to lower blood sugar in people with type 2 diabetes, according to new research.

Natural, edible treatment offers promise for diabetics

June 28, 2013
A potentially revolutionary treatment for diabetics mimics the benefits of major surgery, but achieves the same results without it.

Recommended for you

People who drink 3 to 4 times per week less likely to develop diabetes than those who never drink: study

July 27, 2017
Frequent alcohol consumption is associated with a reduced risk of diabetes in both men and women, according to a new study published in Diabetologia (the journal of the European Association for the Study of Diabetes), with ...

Diabetes can be tracked with our Google searches

July 26, 2017
The emergence of Type 2 Diabetes could be more effectively monitored using our Google searches—helping public health officials keep track of the disease and halt its spread—according to research by the University of Warwick.

Scientists discover a new way to treat type 2 diabetes

July 21, 2017
Medication currently being used to treat obesity is also proving to have significant health benefits for patients with type 2 diabetes. A new study published today in Molecular Metabolism explains how this therapeutic benefit ...

Alzheimer's drug cuts hallmark inflammation related to metabolic syndrome by 25 percent

July 20, 2017
An existing Alzheimer's medication slashes inflammation and insulin resistance in patients with metabolic syndrome, a potential therapeutic intervention for a highly dangerous condition affecting 30 percent of adults in the ...

Diabetes or its precursor affects 100 million Americans

July 19, 2017
Almost one-third of the US population—100 million people—either has diabetes or its precursor condition, known as pre-diabetes, said a government report Tuesday.

One virus may protect against type 1 diabetes, others may increase risk

July 11, 2017
Doctors can't predict who will develop type 1 diabetes, a chronic autoimmune disease in which the immune system destroys the cells needed to control blood-sugar levels, requiring daily insulin injections and continual monitoring.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.