Nontoxic scaffold developed: New skin for chronic wounds

September 2, 2013 by Stefan Kyora, Swiss Federal Laboratories for Materials Science and Technology
Nontoxic scaffold developed: New skin for chronic wounds
Credit: CTI, Alessandro Della Bella

The concept is amazing: a synthetic cell carrier is populated by skin cells and dissolves simultaneously. In just two years, the Lucerne-based company nolax and Empa have developed this project up to a first proof of concept stage.

Over 50 million people worldwide suffer from chronic wounds. The number is steadily growing. Most frequently affected is the growing group of older people who are weakened by diseases such as diabetes.

In the framework of a CTI project the Lucerne-based company nolax and Empa have taken a major step towards solving this problem. They have developed a cell carrier or 'scaffold' from bio-compatible, degradable that should help wounds to heal. This scaffold – a spongy- like foam made of flexible polyurethane – can be adapted to the exact shape of the wound. Over time, the scaffold should be populated by . At the same time the body breaks down the foam. All that should remain is a newly formed layer of skin. There are already cell scaffolds on the market, but they are made of products of animal origin, which not only makes them expensive, but also carries the risk of transmitting animal diseases. There are no such disadvantages when are used as wound healing support materials.

An experienced team

nolax has decades of experience with synthetic materials for technical and medical applications. In 2009 the Lucerne- based SME had its scaffold concept patented. "However, we needed a partner if we were to move from the idea to the stage," explains nolax's Stephan Häfner. The perfect partner was found in Empa. The project was managed by the research institute's Arie Bruinink, a and toxicologist with a broad experience in cytocompatibility testing.

This expertise was needed. Tests with were designed to improve the and structure of the scaffold to make it nontoxic, create an environment that cells would be willing to populate and ensure that it dissolves completely without side effects.

More than a hundred tests

The tests developed by the Empa team mimicked realistic conditions as far as possible. In a highly complex process, Bruinink's team created three-dimensional cell clusters from human cells and observed whether cells from these clusters were able to colonise the scaffold. "This corresponds to the conditions in a wound much better than the usual tests with single cells," explains Bruinink.

"On the basis of the test results, we continued to adapt the formula and improve the structure of the scaffold," says Stephan Häfner, Project Manager at nolax. Both teams worked tremendously quickly. A total of over a hundred experiments were performed."

The results were finally evaluated in an animal model by Brigitte von Rechenberg and Katja Nuss at the University of Zurich. Arie Bruinink is pleased with the results: "In the animal model the closure of the wound with the scaffold was even better than we had hoped at the start of the project." In addition, there were initial signs that scarring would be reduced.

In parallel to further optimising the , nolax is working on a production concept for the next stage of clinical trials. Andreas Dobmann, deputy project manager at nolax, is expecting great things to come of it: "Besides the treatment of , other fields of application are already emerging."

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