A link between type 2 diabetes and mitochondrial function

October 1, 2013, Journal of Clinical Investigation

Type 2 diabetes is a chronic condition that is characterized by resistance to or insufficient production of insulin, a hormone that controls sugar movement into cells. In certain tissues, insulin resistance has been associated with dysfunction of mitochondria, which supply most of the cell's chemical energy.

In this issue of the Journal of Clinical Investigation, C. Ronald Kahn and colleagues at Harvard Medical School evaluated mitochondrial involvement in .

They found that 60 (HSP60), which is involved in import and macromolecule assembly, was required for appropriate mitochondrial function and insulin responses.

Additionally, they demonstrated that leptin, a hormone that regulates metabolism and appetite, was important for HSP60 regulation.

This study provides new insight into type 2 diabetes development and implicates leptin regulation of HSP60 as a potential therapeutic target.

Explore further: Saturated fatty acids lead to mitochondrial dysfunction and insulin resistance

More information: Leptin regulation of Hsp60 impacts hypothalamic insulin signaling, J Clin Invest. DOI: 10.1172/JCI67615

Related Stories

Saturated fatty acids lead to mitochondrial dysfunction and insulin resistance

January 20, 2012
Excessive levels of certain saturated fatty acids cause mitochondria to fragment, leading to insulin resistance in skeletal muscle, a precursor of type 2 diabetes, according to a paper in the January issue of the journal ...

Researchers identify mechanisms that are necessary to live without insulin

September 3, 2013
Several millions of people around the world suffer from insulin deficiencies. Insulin is a hormone, secreted by the beta cells in the pancreas, which plays a major role in the regulation of energy substrates such as glucose. ...

A link between zinc transport and diabetes

September 24, 2013
Individuals with a mutation in the gene encoding a zinc transporter, SLC30A8 have an elevated risk of developing type 2 diabetes. Insulin granules that are released from pancreatic β cells contain high levels of zinc; however, ...

Study findings may explain delayed onset of heart disease in women

September 24, 2013
A biological ability to compensate for the body's reduced response to insulin may explain why women typically develop heart disease 10 years later than men, according to a recent study accepted for publication in The Endocrine ...

The role of beta cell regeneration in type 2 diabetes

October 10, 2012
The World Health Organization (WHO) has declared type 2 diabetes as the epidemic of the 21st century. A study is focusing on understanding the mechanisms underlying insulin resistance and the role of beta-cell regeneration.

Fewer mitochondria in offspring of parents with diabetes

March 26, 2012
(HealthDay) -- Normal-weight, insulin-resistant individuals whose parents have type 2 diabetes have fewer mitochondria in their muscles due to lower expression of lipoprotein lipase (LPL), according to a study published in ...

Recommended for you

Researchers have found that incidence of heart failure was around two-fold higher in people with diabetes

December 11, 2018
Researchers have found that incidence of heart failure was around two-fold higher in people with diabetes.

Millions of low-risk people with diabetes may be testing their blood sugar too often

December 10, 2018
For people with Type 2 diabetes, the task of testing their blood sugar with a fingertip prick and a drop of blood on a special strip of paper becomes part of everyday life.

Very low calorie diets trialled by NHS to tackle diabetes

December 7, 2018
Hundreds of thousands of people will receive NHS help to battle obesity and type 2 diabetes under radical action set out by Simon Stevens, Chief Executive of NHS England.

New therapeutic avenue for type 2 diabetes

December 6, 2018
Restoring the action of insulin is one of the keys to fighting type 2 diabetes. Researchers from Inserm led by Dominique Langin at the Institute of Cardiovascular and Metabolic Diseases (Inserm/Université de Toulouse) are ...

Subtype of immune B cells can delay type 1 diabetes onset in mice

December 6, 2018
A team of researchers at Baylor College of Medicine and the University of Michigan Medical School reports today in the JCI Insight that a subset of immune B cells, known as CD19+IgM+ B cells, can delay the onset of type 1 ...

Is the pancreas regeneration debate settled? An original theory renewed

December 5, 2018
A contentious debate among diabetes researchers has surrounded the regeneration of pancreatic insulin-producing cells: not if these cells regenerate, but rather how.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.