A link between type 2 diabetes and mitochondrial function

October 1, 2013, Journal of Clinical Investigation

Type 2 diabetes is a chronic condition that is characterized by resistance to or insufficient production of insulin, a hormone that controls sugar movement into cells. In certain tissues, insulin resistance has been associated with dysfunction of mitochondria, which supply most of the cell's chemical energy.

In this issue of the Journal of Clinical Investigation, C. Ronald Kahn and colleagues at Harvard Medical School evaluated mitochondrial involvement in .

They found that 60 (HSP60), which is involved in import and macromolecule assembly, was required for appropriate mitochondrial function and insulin responses.

Additionally, they demonstrated that leptin, a hormone that regulates metabolism and appetite, was important for HSP60 regulation.

This study provides new insight into type 2 diabetes development and implicates leptin regulation of HSP60 as a potential therapeutic target.

Explore further: Saturated fatty acids lead to mitochondrial dysfunction and insulin resistance

More information: Leptin regulation of Hsp60 impacts hypothalamic insulin signaling, J Clin Invest. DOI: 10.1172/JCI67615

Related Stories

Saturated fatty acids lead to mitochondrial dysfunction and insulin resistance

January 20, 2012
Excessive levels of certain saturated fatty acids cause mitochondria to fragment, leading to insulin resistance in skeletal muscle, a precursor of type 2 diabetes, according to a paper in the January issue of the journal ...

Researchers identify mechanisms that are necessary to live without insulin

September 3, 2013
Several millions of people around the world suffer from insulin deficiencies. Insulin is a hormone, secreted by the beta cells in the pancreas, which plays a major role in the regulation of energy substrates such as glucose. ...

A link between zinc transport and diabetes

September 24, 2013
Individuals with a mutation in the gene encoding a zinc transporter, SLC30A8 have an elevated risk of developing type 2 diabetes. Insulin granules that are released from pancreatic β cells contain high levels of zinc; however, ...

Study findings may explain delayed onset of heart disease in women

September 24, 2013
A biological ability to compensate for the body's reduced response to insulin may explain why women typically develop heart disease 10 years later than men, according to a recent study accepted for publication in The Endocrine ...

The role of beta cell regeneration in type 2 diabetes

October 10, 2012
The World Health Organization (WHO) has declared type 2 diabetes as the epidemic of the 21st century. A study is focusing on understanding the mechanisms underlying insulin resistance and the role of beta-cell regeneration.

Fewer mitochondria in offspring of parents with diabetes

March 26, 2012
(HealthDay) -- Normal-weight, insulin-resistant individuals whose parents have type 2 diabetes have fewer mitochondria in their muscles due to lower expression of lipoprotein lipase (LPL), according to a study published in ...

Recommended for you

High gluten diet in pregnancy linked to increased risk of diabetes in children

September 19, 2018
A high gluten intake by mothers during pregnancy is associated with an increased risk of their child developing type 1 diabetes, suggests a study published by The BMJ today.

Anti-inflammatory protein promotes healthy gut bacteria to curb obesity

September 19, 2018
Scientists from the UNC School of Medicine discovered that the anti-inflammatory protein NLRP12 normally helps protect mice against obesity and insulin resistance when they are fed a high-fat diet. The researchers also reported ...

Study reveals the current rates of diagnosed type 1 and type 2 diabetes in American adults

September 18, 2018
A new study from the University of Iowa finds that type 2 diabetes remains overwhelmingly the most common type of diabetes diagnosed in American adults who have the disease.

Research reveals link between immunity, diabetes

September 14, 2018
When it comes to diet-induced obesity, your immune system is not always your friend.

BPA exposure in U.S.-approved levels may alter insulin response in non-diabetic adults

September 14, 2018
In a first study of its kind study, researchers have found that a common chemical consumers are exposed to several times a day may be altering insulin release. Results of the study, led by scientists at the University of ...

High blood sugar during pregnancy ups risk of mother's type 2 diabetes, child's obesity

September 11, 2018
Mothers with elevated blood glucose during pregnancy—even if not high enough to meet the traditional definition of gestational diabetes—were significantly more likely to have developed type 2 diabetes a decade after pregnancy ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.