A link between type 2 diabetes and mitochondrial function

October 1, 2013, Journal of Clinical Investigation

Type 2 diabetes is a chronic condition that is characterized by resistance to or insufficient production of insulin, a hormone that controls sugar movement into cells. In certain tissues, insulin resistance has been associated with dysfunction of mitochondria, which supply most of the cell's chemical energy.

In this issue of the Journal of Clinical Investigation, C. Ronald Kahn and colleagues at Harvard Medical School evaluated mitochondrial involvement in .

They found that 60 (HSP60), which is involved in import and macromolecule assembly, was required for appropriate mitochondrial function and insulin responses.

Additionally, they demonstrated that leptin, a hormone that regulates metabolism and appetite, was important for HSP60 regulation.

This study provides new insight into type 2 diabetes development and implicates leptin regulation of HSP60 as a potential therapeutic target.

Explore further: Saturated fatty acids lead to mitochondrial dysfunction and insulin resistance

More information: Leptin regulation of Hsp60 impacts hypothalamic insulin signaling, J Clin Invest. DOI: 10.1172/JCI67615

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