Resveratrol could help treat multiple types of cancer, study finds

October 11, 2013
Nicholl has found that resveratrol, a compound found in grape skins and red wine, can make certain tumor cells more susceptible to radiation treatment. The next step is for researchers to develop a successful method to deliver the compound to tumor sites and potentially treat many types of cancers. Credit: University of Missouri

A recent study by a University of Missouri researcher shows that resveratrol, a compound found in grape skins and red wine, can make certain tumor cells more susceptible to radiation treatment. This research, which studied melanoma cells, follows a previous MU study that found similar results in the treatment of prostate cancer. The next step is for researchers to develop a successful method to deliver the compound to tumor sites and potentially treat many types of cancers.

"Our study investigated how resveratrol and radiotherapy inhibit the survival of melanoma cells," said Michael Nicholl, assistant professor of surgery at the MU School of Medicine and surgical oncologist at Ellis Fischel Cancer Center in Columbia, Mo. "This work expands upon our previous success with resveratrol and in prostate . Because of difficulties involved in delivery of adequate amounts of resveratrol to melanoma tumors, the compound is probably not an effective treatment for advanced melanoma at this time."

The study found that become more susceptible to radiation if they were treated first with resveratrol. The MU researcher found that when the cancer was treated with resveratrol alone, 44 percent of the tumor cells were killed. When the cancer cells were treated with a combination of both resveratrol and radiation, 65 percent of the died.

Nicholl said his findings could lead to more research into the cancer-fighting benefits of the naturally occurring compound.

The video will load shortly.
A recent study by a University of Missouri researcher shows that resveratrol, a compound found in grape skins and red wine, can make certain tumor cells more susceptible to radiation treatment. Credit: University of Missouri

"We've seen glimmers of possibilities, and it seems that resveratrol could potentially be very important in treating a variety of cancers," Nicholl said. "It comes down to how to administer the resveratrol. If we can develop a successful way to deliver the compound to tumor sites, resveratrol could potentially be used to treat many types of cancers. Melanoma is very tricky due to the nature of how the cancer travel throughout the body, but we envision resveratrol could be combined with radiation to treat symptomatic metastatic tumors, which can develop in the brain or bone."

Resveratrol supplements are available over the counter in many health food sections at grocery stores. Nicholl does not recommend that patients rely on supplements to treat cancer because more research is needed.

Nicholl's study was published in the Journal of Surgical Research, the journal for the Association for Academic Surgery. If additional studies are successful within the next few years, MU officials will request authority from the federal government to begin human drug development. This is commonly referred to as the "investigative new drug" status. After this status has been granted, researchers may conduct clinical trials with the hope of developing new treatments for cancer.

Explore further: Compound in grapes, red wine could be key to fighting prostate cancer

Related Stories

Compound in grapes, red wine could be key to fighting prostate cancer

November 10, 2012
Resveratrol, a compound found commonly in grape skins and red wine, has been shown to have several beneficial effects on human health, including cardiovascular health and stroke prevention. Now, a University of Missouri researcher ...

Resveratrol remains effective against cancer after the body converts it

October 2, 2013
A chemical found in red wine remains effective at fighting cancer even after the body's metabolism has converted it into other compounds. This is an important finding in a new paper published in the journal Science Translational ...

A sip of resveratrol and a full p53: Ingredients for a successful cell death

November 13, 2012
Researchers at the Universidade Federal in Rio de Janeiro in Brazil have found that introduction of a normal copy of the p53 gene in p53-defective cancer cell lines makes these cells sensitive to the anti-tumor proprieties ...

Red wine ingredient resveratrol stops breast cancer growth

September 29, 2011
Cheers! A new research report appearing in the October 2011 issue of The FASEB Journal shows that resveratrol, the "healthy" ingredient in red wine, stops breast cancer cells from growing by blocking the growth effects of ...

Team designing new drug for common heart condition

October 7, 2013
An international research team led by medical scientists at the University of Alberta has shown that new medications based on resveratrol—a compound found in red wine and nuts—may be used to treat a common heart-rhythm ...

New evidence on how compound found in red wine can help prevent cancer

December 4, 2012
(Medical Xpress)—University of Leicester scientists will present groundbreaking new evidence about how a chemical found in red wine can help prevent cancer on Wednesday, December 5.

Recommended for you

Cell-based therapy success could be boosted by new antioxidant

September 19, 2017
Cell therapies being developed to treat a range of conditions could be improved by a chemical compound that aids their survival, research suggests.

New model may help science overcome the brain's fortress-like barrier

September 19, 2017
Scientists have helped provide a way to better understand how to enable drugs to enter the brain and how cancer cells make it past the blood brain barrier.

Study suggests epilepsy drug can be used to treat form of dwarfism

September 19, 2017
A drug used to treat conditions such as epilepsy has been shown in lab tests at The University of Manchester to significantly improve bone growth impaired by a form of dwarfism.

Research predicts how patients are likely to respond to DNA drugs

September 19, 2017
Research carried out by academics at Northumbria University, Newcastle could lead to improvements in treating patients with diseases caused by mutations in genes, such as cancer, cystic fibrosis and potentially up to 6,000 ...

Urine output to disease: Study sheds light on the importance of hormone quality control

September 18, 2017
The discovery of a puddle of mouse urine seems like a strange scientific "eureka" moment.

New lung cell type discovered

September 18, 2017
A recent study has identified a new lung cell type that is implicated in the body's innate immune defense against the bacteria Streptococcus pneumoniae—one of the leading causes of pneumonia worldwide.

2 comments

Adjust slider to filter visible comments by rank

Display comments: newest first

jamesinraro
1 / 5 (1) Oct 11, 2013
Two specific resveratrol forms, Bioforte and Transmax resveratrol, have become the default choice of the medical research community in its investigations of this compound due to their consistent performance in clinical trials. Bioforte and Transmax have been the active ingredient used in medical school studies done in the UK, the US, Canada, Australia, Europe and Asia. One of the explanations for the singularly impressive results from these two resveratrol forms is that the generic form of the compound suffers from two disadvantages as a supplement.  First, its bioavailability, as with most phytochemicals, is low, therefore a means of improving this property is needed to insure assimilation and utilisation by the body.  This is accomplished in Bioforte and Transmax by a proprietary technology which sustains the release of the resveratrol over a longer period in the blood plasma, without sacrificing the valuable metabolites.  Second, resveratrol is subject to rapid disintegration
ian_liberman
1 / 5 (1) Oct 12, 2013
The University of Leicester's Department of Cancer Studies and Molecular Medicine has just recently found that Resveratrol stays in the body long enough to be effective against cancer after the body converts it . The head of the study claims that regular supplements should be effective . http://www.ingred...verts-it

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.