Study uncovers potential to alleviate tissue damage during strokes or transplant

October 29, 2013 by Helen Dodson, Yale University
Study uncovers potential to alleviate tissue damage during strokes or transplant
Credit: Shutterstock

A new study from Yale School of Medicine uncovers clues as to how a key part of the immune system is regulated to avoid tissue injury to human organs after stroke or transplant. The study, in the journal Developmental Cell, focuses on a type of white blood cell called a neutrophil, and how regulation of the granules inside can protect organs such as kidneys from injury.

The research team uncovered a previously unknown role of a protein complex of STK24 and CCM3 in regulating the release of granules from neutrophils. The complex acted in a way that prevented the release of too many , which would acerbate damage.

Senior author Dianqing Wu, professor of pharmacology, explains the implications of the study for stroke patients and those who have undergone tissue transplants. "This study provides potential new therapeutic targets to alleviate during strokes and tissue transplantation," he said.

Wu added, "This study, by revealing the basic cellular function of CCM3, also points a new direction for the investigation of the pathogenic basis for Cerebral Cavernous Malformation (CCM) disease." CCM is a life-threatening neurovascular disease, which can be caused by mutations in CCM3. 

Explore further: Peritoneal dialysis as an intervention for stroke patients

More information: www.cell.com/developmental-cel … 1534-5807(13)00569-8

Related Stories

Peritoneal dialysis as an intervention for stroke patients

September 3, 2013
Ischemic stroke is characterized by an interruption of the blood supply to the brain, which can lead to brain damage and even death. Excess amounts of the excitatory neurotransmitter glutamate are released during stroke events ...

A surprise mechanism uncovered in the development of lupus

October 25, 2012
In a study with a surprising outcome, scientists at Yale School of Medicine have discovered that an enzyme complex known for promoting natural resistance to bacteria and fungi unexpectedly inhibits the development of lupus. ...

Could a 'Trojan horse' better identify traumatic brain injury?

October 28, 2013
Accurately diagnosing traumatic brain injuries and concussions is difficult, as standard CT or MRI scans can't see most changes to the brain caused by these injuries.

Stopping cell migration may help block fibrosis and the spread of cancer

May 21, 2012
(Medical Xpress) -- Discoveries by a Yale-led team of scientists could lead the way for development of new therapies for treating fibrosis and tumor metastasis. The researchers have both uncovered a signaling pathway that ...

Recommended for you

How metal scaffolds enhance the bone healing process

January 22, 2018
A new study shows how mechanically optimized constructs known as titanium-mesh scaffolds can optimize bone regeneration. The induction of bone regeneration is of importance when treating large bone defects. As demonstrated ...

Bioengineered soft microfibers improve T-cell production

January 18, 2018
T cells play a key role in the body's immune response against pathogens. As a new class of therapeutic approaches, T cells are being harnessed to fight cancer, promising more precise, longer-lasting mitigation than traditional, ...

Weight flux alters molecular profile, study finds

January 17, 2018
The human body undergoes dramatic changes during even short periods of weight gain and loss, according to a study led by researchers at the Stanford University School of Medicine.

Secrets of longevity protein revealed in new study

January 17, 2018
Named after the Greek goddess who spun the thread of life, Klotho proteins play an important role in the regulation of longevity and metabolism. In a recent Yale-led study, researchers revealed the three-dimensional structure ...

The HLF gene protects blood stem cells by maintaining them in a resting state

January 17, 2018
The HLF gene is necessary for maintaining blood stem cells in a resting state, which is crucial for ensuring normal blood production. This has been shown by a new research study from Lund University in Sweden published in ...

Magnetically applied MicroRNAs could one day help relieve constipation

January 17, 2018
Constipation is an underestimated and debilitating medical issue related to the opioid epidemic. As a growing concern, researchers look to new tools to help patients with this side effect of opioid use and aging.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.