(HealthDay)—There are significant regional differences in spending on vascular care in patients who ultimately need amputation for severe peripheral arterial disease, according to a study published online Nov. 20 in JAMA Surgery.

Philip P. Goodney, M.D., from the Dartmouth-Hitchcock Medical Center in Lebanon, N.H., and colleagues retrospectively analyzed data on 18,463 U.S. Medicare patients who underwent a major -related amputation from 2003 to 2010. Data were correlated to price-adjusted Medicare spending on and related vascular care in the year before amputation, across hospital referral regions.

The researchers found that among patients undergoing an amputation, 64 percent were admitted to the hospital in the previous year for revascularization, wound-related care, or both. Including the year before amputation, the mean cost of inpatient care (including the amputation procedure itself) was $22,405, but ranged significantly from $11,077 (Bismarck, N.D.) to $42,613 (Salinas, Calif.) (P < 0.001). Vascular procedures were significantly more likely to be performed in patients in high-spending regions, both in crude analyses (P < 0.001) and in risk-adjusted analyses (P < 0.001). While revascularization was associated with higher spending (P < 0.001), higher spending was not associated with lower regional amputation rates (P = 0.06).

"There is little evidence that higher regional spending is associated with lower rates," the authors write.