Alendronate reduces adjacent-level vertebral fractures

December 30, 2013
Alendronate reduces adjacent-level vertebral fractures

(HealthDay)—For females with osteoporosis, the rate of adjacent-level vertebral fractures is relatively low, with reduced odds with bisphosphonate therapy, according to a study published in the Dec. 1 issue of Spine.

Bruce Frankel, M.D., from the Medical University of South Carolina in Charleston, and colleagues examined the risk of adjacent-level in patients with osteoporosis using data from a large, randomized fracture intervention trial of alendronate treatment. Incident morphometric fracture rates were assessed for bisphosphonate-treated and bisphosphonate-naive patients (1,950 participants).

During a mean follow-up of 2.9 years, the researchers identified adjacent-level vertebral fractures in 3.4 percent of patients in the alendronate group and 7.4 percent of patients in the placebo group, with annual rates of 1.2 and 2.5 percent, respectively. The thoracolumbar region (T11, T12, and L1) seemed to be the most prone to new adjacent-level fractures. In univariate analysis, at randomization, lower bone , inactivity, and placebo therapy correlated significantly with adjacent-level fractures (P ≤ 0.05). The odds of adjacent-level fractures were decreased with bisphosphonate therapy and higher bone mineral density, and were increased with older age at randomization, in multivariate analysis (P ≤ 0.05).

"New vertebral fractures adjacent to prevalent fractures occurred relatively infrequently in this treatment trial of alendronate in females with , and were more common with older age at randomization, lower and placebo treatment," the authors write.

Relevant financial activities outside the submitted work were disclosed: consultancy, grants, patents, royalties.

Explore further: Calcium and vitamin D improve bone density in patients taking antiepileptic drugs

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Calcium and vitamin D improve bone density in patients taking antiepileptic drugs

November 7, 2013
A recent prospective, randomized, placebo-controlled clinical trial reports that calcium and vitamin D supplementation improves bone density in a group of male veterans with epilepsy who were treated chronically with antiepileptic ...

Once-yearly zoledronic acid benefits men with osteoporosis

November 2, 2012
(HealthDay)—For men with osteoporosis, a once-yearly infusion with zoledronic acid is associated with fewer vertebral fractures and improved bone health compared with placebo, according to a study published in the Nov. ...

The deadly news about all osteoporotic fractures

November 27, 2013
It is well known that hip and vertebral fractures increase the risk of premature death. Until now, little has been known about the clinical impact of non-hip, non-vertebral fractures – so new Australian research showing ...

Not only bone density, but also quality of bone predicts fracture risk

August 5, 2013
In a study carried out at the University of Eastern Finland, bone histomorphometry and infrared spectroscopy revealed abnormal bone properties in children with vertebral fractures and in children after solid organ transplantation. ...

Hong Kong study shows lower survival rates after second hip fractures

December 15, 2013
Research presented today at the 4th Asia-Pacific Osteoporosis Meeting showed that second hip fractures are more deadly than first hip fractures. Based in Hong Kong, the study evaluated the overall incidence of a second hip ...

Bone metabolism, vitamin D key in postkyphoplasty breaks

April 25, 2012
(HealthDay) -- For postmenopausal women with osteoporosis, bone metabolism and 25-hydroxyvitamin D (25[OH]D) levels are associated with postkyphoplasty recurrent vertebral compression fractures, according to a study published ...

Recommended for you

Past encounters with the flu shape vaccine response

February 20, 2018
New research on why the influenza vaccine was only modestly effective in recent years shows that immune history with the flu influences a person's response to the vaccine.

Building better tiny kidneys to test drugs and help people avoid dialysis

February 16, 2018
A free online kidney atlas built by USC researchers empowers stem cell scientists everywhere to generate more human-like tiny kidneys for testing new drugs and creating renal replacement therapies.

Expanding Hepatitis C testing to all adults is cost-effective and improves outcomes

February 16, 2018
According to a new study, screening all adults for hepatitis C (HCV) is a cost-effective way to improve clinical outcomes of HCV and identify more infected people compared to current recommendations. Using a simulation model, ...

Study suggests expanded range for emerging tick-borne disease

February 16, 2018
Human cases of Borrelia miyamotoi, a tick-borne infection with some similarities to Lyme disease, were discovered in the eastern United States less than a decade ago. Now new research led by the Yale School of Public Health ...

Flu shot only 36 percent effective, making bad year worse (Update)

February 15, 2018
The flu vaccine is doing a poor job protecting older Americans and others against the bug that's causing most illnesses.

IFN-mediated immunity to influenza A virus infection influenced by RIPK3 protein

February 15, 2018
Each year, influenza kills half a million people globally with the elderly and very young most often the victims. In fact, the Centers for Disease Control and Prevention reported 37 children have died in the United States ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.