Biomarker identified in systemic sclerosis predicts progression

December 19, 2013
Biomarker identified in systemic sclerosis predicts progression

(HealthDay)—Patients with systemic sclerosis have elevated levels of CXCL4, which predicts disease risk and progression, according to a study published online Dec. 18 in the New England Journal of Medicine.

Lenny van Bon, M.D., from the Boston University School of Medicine, and colleagues performed proteome-wide analysis using isolated from healthy individuals and from patients with systemic sclerosis with distinct clinical phenotypes. The findings were validated in five large cohorts of patients with systemic sclerosis, and were compared with those for patients with systemic lupus erythematosus, ankylosing spondylitis, and hepatic fibrosis.

The researchers found that, in systemic sclerosis, the predominant protein secreted by plasmacytoid dendritic cells in circulation and in skin was CXCL4, with a mean level of 25,624 pg/mL, which was significantly higher than that found in controls (92.5 pg/mL) or in patients with (1,346 pg/mL), ankylosing spondylitis (1,368 pg/mL), or liver fibrosis (1,668 pg/mL). There was a correlation between CXCL4 levels and skin and lung fibrosis and pulmonary arterial hypertension. Of the chemokines, only CXCL4 predicted systemic sclerosis risk and progression. CXCL4 induced inflammatory cell influx and skin transcriptome changes in vivo.

"Levels of CXCL4 were elevated in patients with and correlated with the presence and progression of complications, such as lung fibrosis and ," the authors write.

Explore further: Updated systemic sclerosis criteria improve disease classification

More information: Full Text

Related Stories

Updated systemic sclerosis criteria improve disease classification

October 3, 2013
New classification criteria for systemic sclerosis have just been published and are more sensitive than the 1980 criteria, enabling earlier identification and treatment of this disabling autoimmune disease. The 2013 criteria, ...

Researchers identify likely causes, treatment strategies for systemic scleroderma

October 9, 2013
Using mice, lab-grown cells and clues from a related disorder, Johns Hopkins researchers have greatly increased understanding of the causes of systemic sclerosis, showing that a critical culprit is a defect in the way certain ...

Systemic sclerosis complications more severe in African Americans than Caucasians

May 10, 2012
African Americans have more severe complications from systemic sclerosis, also known as scleroderma, than Caucasians. Findings published today in, Arthritis & Rheumatism, a journal of the American College of Rheumatology ...

New treatment for disfiguring skin condition

December 9, 2013
Researchers from The University of Manchester and Salford Royal NHS Foundation Trust have tested a new way to treat a disfiguring skin condition.

Haematopoietic stem cell transplantation increases survival in systemic sclerosis patients

June 7, 2012
Initial results from an international, investigator-initiated, open label phase III trial were presented at EULAR 2012, the Annual Congress of the European League Against Rheumatism. Data indicate that haematopoietic stem ...

Study suggests systemic sclerosis is an independent risk factor for atherosclerosis

May 10, 2011
A new study by researchers in Hong Kong suggests that systemic sclerosis is an independent determinant for moderate to severe coronary calcification or atherosclerosis. Conventional cardiovascular risk factors such as age ...

Recommended for you

Novel approach to track HIV infection

August 18, 2017
Northwestern Medicine scientists have developed a novel method of tracking HIV infection, allowing the behavior of individual virions—infectious particles—to be connected to infectivity.

Faulty gene linked to obesity in adults

August 18, 2017
Groundbreaking new research linking obesity and metabolic dysfunction to a problem in the energy generators in cells has been published by researchers from the Harry Perkins Institute of Medical Research and The University ...

Two lung diseases killed 3.6 million in 2015: study

August 17, 2017
The two most common chronic lung diseases claimed 3.6 million lives worldwide in 2015, according to a tally published Thursday in The Lancet Respiratory Medicine.

New test differentiates between Lyme disease, similar illness

August 16, 2017
Lyme disease is the most commonly reported vector-borne illness in the United States. But it can be confused with similar conditions, including Southern Tick-Associated Rash Illness. A team of researchers led by Colorado ...

Addressing superbug resistance with phage therapy

August 16, 2017
International research involving a Monash biologist shows that bacteriophage therapy – a process whereby bacterial viruses attack and destroy specific strains of bacteria - can be used successfully to treat systemic, multidrug ...

Can previous exposure to west Nile alter the course of Zika?

August 15, 2017
West Nile virus is no stranger to the U.S.-Mexico border; thousands of people in the region have contracted the mosquito-borne virus in the past. But could this previous exposure affect how intensely Zika sickens someone ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.