Chickenpox vaccine not responsible for rise in shingles, study says

December 2, 2013 by Serena Gordon, Healthday Reporter
Chickenpox vaccine not responsible for rise in shingles, study says
39 percent increase over 18 years remains unexplained.

(HealthDay)—The prevalence of a painful condition known as shingles is increasing in the United States, but new research says the chickenpox vaccine isn't to blame.

Shingles is caused by the same virus that causes chickenpox, the . Researchers have theorized that widespread chickenpox vaccination since the 1990s might have given shingles an unintended boost. But that theory didn't pan out in a study of nearly 3 million older adults.

"The program was introduced in 1996, so we looked at the incidence of shingles from the early '90s to 2010, and found that shingles was already increasing before the vaccine program started," said study author Dr. Craig Hales, a medical epidemiologist at the U.S. Centers for Disease Control and Prevention. "And as immunization coverage in children reached 90 percent, shingles continued at the same rate."

Once someone has had chickenpox, the varicella zoster virus stays in the body. It lies dormant for years, often even for decades, but then something happens to reactivate it. When it's reactivated, it's called herpes zoster or shingles.

Exposure to children with chickenpox boosts adults' immunity to the virus, Hales explained. But experts wondered if vaccinating a whole generation of children against chickenpox might affect the rate of shingles in older people, who have already been exposed to the chickenpox virus.

"Our immunity naturally wanes over time, and once it wanes enough, that's when the virus can reactivate," said Hales. "So, if we're never exposed to children with chickenpox, would we lose that normal immunity boost?"

To answer this question, Hales and his colleagues reviewed Medicare claims data from 1992 to 2010 that included about 2.8 million people over the age of 65.

They found that annual rates of shingles increased 39 percent over the 18-year study period. However, they didn't find a statistically significant change in the rate after the introduction of the chickenpox vaccine. They also found that the rate of shingles didn't vary from state to state where there were different rates of chickenpox vaccine coverage.

These findings, published in the Dec. 3 issue of the Annals of Internal Medicine, suggest the chickenpox vaccine isn't related to the increase in shingles, according to Hales.

So what might be responsible for the increase in shingles?

Hales says experts aren't sure. "We really don't know why about one-third to one-quarter of people who've had chickenpox go on to develop shingles over their lifetime while others don't," he explained.

Hales did note that conditions and treatments that can compromise the body's immune system have increased in recent years. "We thought perhaps that might explain the rise," said Hales. "But we selected for people who didn't have any diseases or take any medications that suppress the immune system, and we still saw an increase in shingles."

He said the researchers also thought reported cases of shingles could be increasing because more people might see doctors as exposure to medical knowledge increases. But they found that the incidence of shingles was going up faster than the incidence of other conditions. If the increase in shingles were due to more people going to the doctor, the incidence of other medical disorders would also be rising, Hales said.

In the future, Hales said that because of the chickenpox vaccine, "shingles should be a relatively rare disease." That's because youngsters who are vaccinated will never have had the initial infection with the varicella zoster virus.

In the meantime, people who've had chickenpox should consider getting the shingles vaccine. And that means just about everyone. "Almost 100 percent of people in the U.S. have been affected by varicella zoster," Hales said. The CDC recommends the one-time vaccine for anyone aged 60 or older.

Dr. Kenneth Bromberg, director of the Vaccine Research Center at the Brooklyn Hospital Center in New York City, echoed that recommendation.

"So far, we don't know why there's more shingles. But, there is a vaccine that can prevent it," said Bromberg.

Shingles occurs most often in people older than 50. Early symptoms usually include mild to severe burning or shooting pain on one side of the body or face. Rashes or blisters emerge after that, and pain from can continue for weeks, months or even years.

Explore further: Shingles vaccine prevents painful disease in older adults

More information: Learn more about the shingles vaccine from the U.S. Centers for Disease Control and Prevention.

Related Stories

Shingles vaccine prevents painful disease in older adults

October 17, 2012
Older adults who get the shingles vaccine have a nearly 50 percent reduced risk of developing the often debilitating disease, finds a new evidence review from The Cochrane Library.

Study suggests link between untreated depression and response to shingles vaccine

February 14, 2013
Results from a new study published in Clinical Infectious Diseases suggest a link between untreated depression in older adults and decreased effectiveness of the herpes zoster, or shingles, vaccine. Older adults are known ...

Shingles vaccine is associated with reduction in both postherpetic neuralgia and herpes zoster

April 9, 2013
Shingles vaccine is associated with reduction in both postherpetic neuralgia and herpes zoster, but uptake in the US is low.

Short-term risk of shingles recurrence low

June 5, 2012
People who have had an episode of herpes zoster, also known as shingles, face a relatively low short-term risk of developing shingles, according to a Kaiser Permanente Southern California study published online in the Journal ...

Shingles vaccination is a must, says microbiologist

February 7, 2013
Terry D. Connell, PhD, knows a lot about the immune system: he's a University at Buffalo professor in the Department of Microbiology and Immunology in the School of Medicine and Biomedical Sciences who conducts research on ...

Recommended for you

Novel approach to track HIV infection

August 18, 2017
Northwestern Medicine scientists have developed a novel method of tracking HIV infection, allowing the behavior of individual virions—infectious particles—to be connected to infectivity.

Faulty gene linked to obesity in adults

August 18, 2017
Groundbreaking new research linking obesity and metabolic dysfunction to a problem in the energy generators in cells has been published by researchers from the Harry Perkins Institute of Medical Research and The University ...

Two lung diseases killed 3.6 million in 2015: study

August 17, 2017
The two most common chronic lung diseases claimed 3.6 million lives worldwide in 2015, according to a tally published Thursday in The Lancet Respiratory Medicine.

New test differentiates between Lyme disease, similar illness

August 16, 2017
Lyme disease is the most commonly reported vector-borne illness in the United States. But it can be confused with similar conditions, including Southern Tick-Associated Rash Illness. A team of researchers led by Colorado ...

Addressing superbug resistance with phage therapy

August 16, 2017
International research involving a Monash biologist shows that bacteriophage therapy – a process whereby bacterial viruses attack and destroy specific strains of bacteria - can be used successfully to treat systemic, multidrug ...

Can previous exposure to west Nile alter the course of Zika?

August 15, 2017
West Nile virus is no stranger to the U.S.-Mexico border; thousands of people in the region have contracted the mosquito-borne virus in the past. But could this previous exposure affect how intensely Zika sickens someone ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.