Insight into likelihood of retinal detachment following open globe injury

January 1, 2014

Ocular trauma causing open globe injury, or a breach in the wall of the eye, remains an important cause of vision loss, with more than 200,000 open globe injuries occurring worldwide each year. In many cases, retinal detachment follows the traumatic injury, causing significant vision loss or blindness.

Researchers from the Massachusetts Eye and Ear, Harvard Vanguard Medical Associates and Harvard Medical School Department of Ophthalmology report on the first study in 35 years that reviews the circumstances around retinal detachment after open globe injuries (OGI) and describes a new tool that may help ophthalmologists predict which patients are at higher risk after open globe trauma so they can potentially prevent retinal detachment from happening or identify – and repair – it more quickly, thus saving vision. The paper is posted online in the journal Ophthalmology and slated for the January print edition of that publication.

Researchers performed a retrospective review of 1,036 consecutive OGIs evaluated by the Eye Trauma Service of the Massachusetts Eye and Ear from Feb. 1, 1999, to Nov. 30, 2011. A total of 143 charts were unavailable for review or incomplete and so were excluded from analysis, yielding a total cohort of 893 eyes. Open globe injuries were treated urgently at presentation. After open globe primary repair, patients were admitted for 48 hours of intravenous antibiotics.

Demographic and clinical data from these 893 charts were entered into a database. Variables included were age, sex, date, time and place of injury, mechanism of injury, initial clinical findings, date and time of open globe repair, ocular trauma score, zone of , date of retinal detachment diagnosis, date of retinal detachment surgery, and last date of follow-up (censoring date).

Patients who developed retinal detachment were older (mean age, 46 vs. 38 years; P < 0.0001), had a poorer median visual acuity (light perception vs. 20/400; P < 0.001), were less likely to have a visual acuity of ≥20/200 (1.6% vs. 43%; P < 0.001), were more likely to have an afferent pupillary defect (34% vs. 8%; P < 0.001), and were more likely to have vitreous hemorrhage (85% vs. 32%; P < 0.001) compared with patients who did not develop RD. In both groups, most patients were male (78% vs. 80%; P = 0.65).

"We took this information, along with other variables, and created the Retinal Detachment after Open Globe Injury (RD-OGI) score," said Dean Eliott, M.D., senior author, associate director of the Mass. Eye and Ear Retina Service and Stelios Evangelos Gragoudas Associate Professor of Ophthalmology, Harvard Medical School. "After prospective validation with independent cohorts, the RD-OGI score may be useful to help the ophthalmologist predict which patients are at higher risk for after open globe trauma."

Explore further: Study finds no increased risk of retinal detachment with use of certain antibiotics

More information: www.aaojournal.org/article/S01 … (13)00582-4/abstract

Related Stories

Study finds no increased risk of retinal detachment with use of certain antibiotics

November 26, 2013
In contrast to findings of a recent study, researchers in Denmark did not find an association between use of a class of antibiotics known as fluoroquinolones (such as ciprofloxacin) and an increased risk of retinal detachment, ...

Children born prematurely face up to a 19 times greater risk of retinal detachment later in life

November 7, 2013
Children born extremely prematurely have up to a 19 times greater risk of retinal detachment later in life than peers born at term, according to a Swedish study published this month in Ophthalmology, the journal of the American ...

Ranibizumab may prevent retinal detachment side effect

April 9, 2013
Proliferative vitreoretinopathy (PVR), or the formation of scar tissue in the eye, is a serious, sight-threatening complication in people recovering from surgical repair of retinal detachment. PVR is difficult to predict, ...

New view of origins of eye diseases

April 3, 2013
Using new technology and new approaches, researchers at Lund University in Sweden hope to be able to explain why people suffer vision loss in eye diseases such as retinal detachment and glaucoma.

Watch out for eyes when champagne corks fly

December 30, 2012
(HealthDay)—If you plan to pop a bottle of Champagne or sparkling wine over the holidays, make sure you do it safely, the American Academy of Ophthalmology says.

Recommended for you

Genome editing with CRISPR-Cas9 prevents angiogenesis of the retina

July 24, 2017
A research team from the Schepens Eye Research Institute of Massachusetts Eye and Ear has successfully prevented mice from developing angiogenesis of the retina—the sensory tissue at the back of the eye—using gene-editing ...

Too little vitamin D may hinder recovery of injured corneas

July 24, 2017
Injury or disease in combination with too little vitamin D can be bad for the window to your eyes.

Combination of type 2 diabetes and sleep apnoea indicates eyesight loss within four years

July 4, 2017
Research led by the University of Birmingham has discovered that patients who suffer from both Type 2 diabetes and obstructive sleep apnoea are at greater risk of developing a condition that leads to blindness within an average ...

Nearly 60% of pinkeye patients receive antibiotic eye drops, but they're seldom necessary

June 28, 2017
A new study suggests that most people with acute conjunctivitis, or pinkeye, are getting the wrong treatment.

Magnetic implants used to treat 'dancing eyes'

June 26, 2017
A research team has successfully used magnets implanted behind a person's eyes to treat nystagmus, a condition characterised by involuntary eye movements.

Drug shows promise against vision-robbing disease in seniors

June 21, 2017
An experimental drug is showing promise against an untreatable eye disease that blinds older adults—and intriguingly, it seems to work in patients who carry a particular gene flaw that fuels the damage to their vision.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.