Isotonic fluids safer for pediatric maintenance IV therapy

Isotonic fluids safer for pediatric maintenance IV therapy
For children requiring maintenance intravenous fluids, isotonic fluids are safer than hypotonic fluids in terms of plasma sodium levels, according to a meta-analysis published online Dec. 30 in Pediatrics.

(HealthDay)—For children requiring maintenance intravenous (IV) fluids, isotonic fluids are safer than hypotonic fluids in terms of plasma sodium (pNa) levels, according to a meta-analysis published online Dec. 30 in Pediatrics.

Jingjing Wang, M.D., from the Second Affiliated Hospital of Medical School of Xi'an Jiaotong University in China, and colleagues conducted a systematic literature review and assessed evidence from 10 to compare the safety of isotonic versus hypotonic IV maintenance in hospitalized . A meta-analysis was conducted to assess the risks of developing hyponatremia (pNa < 136 mmol/L), severe hyponatremia (pNa < 130 mmol/L), and hypernatremia (pNa > 145 mmol/L).

The researchers found that the risks for developing hyponatremia and severe hyponatremia were significantly increased with hypotonic IV fluids (relative risks, 2.24 and 5.29, respectively). Children who received hypotonic fluids experienced a significantly greater fall in pNa than those who received isotonic fluids (−3.49 mmol/L). The risk of hypernatremia was not significantly different between the intervention groups (relative risk, 0.73; 95 percent confidence interval, 0.22 to 2.48).

"Overall, isotonic fluids are safer than hypotonic fluids in hospitalized children requiring maintenance IV fluid therapy in terms of pNa levels," the authors write.


Explore further

IV fluids used by NHS responsible for unnecessary deaths

More information: Abstract
Full Text (subscription or payment may be required)
Journal information: Pediatrics

Copyright © 2014 HealthDay. All rights reserved.

Citation: Isotonic fluids safer for pediatric maintenance IV therapy (2014, January 3) retrieved 19 September 2019 from https://medicalxpress.com/news/2014-01-isotonic-fluids-safer-pediatric-maintenance.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more