Six percent of colorectal cancer found to be interval tumors

April 16, 2014
Six percent of colorectal cancer found to be interval tumors

(HealthDay)—Six percent of patients with colorectal cancer (CRC) have interval cancers, which develop within six to 60 months of colonoscopy, according to a study published in the April issue of Gastroenterology.

N. Jewel Samadder, M.D., from the University of Utah in Salt Lake City, and colleagues examined the proportion, characteristics, and factors that predict interval CRCs in a population-based study of Utah residents. Participants included 126,851 individuals who underwent colonoscopy examinations from 1995 through 2009. Colonoscopy results were linked with cancer histories to identify patients who underwent colonoscopy six to 60 months before CRC diagnosis.

The researchers identified 2,659 diagnoses of CRC, of which 6 percent developed within six to 60 months of colonoscopy. There was no correlation between sex and age and interval CRCs. Compared with patients found to have CRC detected at colonoscopy or patients who did not develop , a higher percentage of patients with interval CRC had adenomas at their index colonoscopy (57.2 versus 36 and 26 percent, respectively; P < 0.001). Compared with tumors detected at index colonoscopy, interval CRCs tended to be earlier stage and proximally located (odds ratio, 2.24; P < 0.001). Compared with patients found to have CRC at their index colonoscopy, with interval CRC were more likely to have family history of CRC (odds ratio, 2.27; P = 0.008) and had a lower risk of death (hazard ratio, 0.63; P < 0.001).

"These findings indicate that interval colorectal tumors may arise as the result of distinct biologic features and/or suboptimal management of polyps at ," the authors write.

Two authors disclosed financial ties to the biotechnology and medical device industries.

Explore further: Post-polyp detection, CRC risk ID'd by colonoscopy factors

More information: Abstract
Full Text

Related Stories

Post-polyp detection, CRC risk ID'd by colonoscopy factors

August 21, 2012
(HealthDay) -- In the community setting, after colonoscopic polyp detection, colonoscopy-related factors such as incomplete polyp removal and lack of surveillance colonoscopies are more important than polyp characteristics ...

Effect of mailed outreach invitations to underserved patients for colorectal cancer screening

August 5, 2013
Among underserved patients whose colorectal cancer (CRC) screening was not up to date, mailed outreach invitations appear to result in higher CRC screening compared with usual care, according to a study by Samir Gupta, M.D., ...

Surveillance colonoscopy recommendations for average-risk patients with 1 to 2 small polyps consistent with guidelines

April 16, 2014
According to a new study, endoscopists' recommendations for timing of surveillance colonoscopy in average-risk patients with one to two small polyps are consistent with guideline recommendations in about 90 percent of cases. ...

Reduced efficacy for CRC screenings done by non-GI docs

June 22, 2012
(HealthDay) -- Having interval colorectal cancer (CRC) colonoscopy screenings performed by nongastroenterologists compared with gastroenterologists (GIs) results in a noticeable reduction in the long-term CRC prevention rate, ...

Patient activation predicts bowel preparation quality

March 3, 2014
(HealthDay)—Lower patient activation, but not limited health literacy, is an independent predictor of suboptimal colonoscopy bowel preparation quality, according to a study published in the March issue of Clinical Gastroenterology ...

Prevalence, predictors of interval colorectal cancer ID'd

June 8, 2012
(HealthDay) -- A variety of procedural and biologic factors contribute to the development of interval colorectal cancers, seen in 7.2 percent of Medicare beneficiaries, according to a study published in the June 15 issue ...

Recommended for you

Single blood test screens for eight cancer types

January 18, 2018
Johns Hopkins Kimmel Cancer Center researchers developed a single blood test that screens for eight common cancer types and helps identify the location of the cancer.

How cancer metastasis happens: Researchers reveal a key mechanism

January 18, 2018
Cancer metastasis, the migration of cells from a primary tumor to form distant tumors in the body, can be triggered by a chronic leakage of DNA within tumor cells, according to a team led by Weill Cornell Medicine and Memorial ...

These foods may up your odds for colon cancer

January 18, 2018
(HealthDay)—Chowing down on red meat, white bread and sugar-laden drinks might increase your long-term risk of colon cancer, a new study suggests.

The pill lowers ovarian cancer risk, even for smokers

January 18, 2018
(HealthDay)—It's known that use of the birth control pill is tied to lower odds for ovarian cancer, but new research shows the benefit extends to smokers or women who are obese.

Researchers find a way to 'starve' cancer

January 18, 2018
Researchers at Vanderbilt University Medical Center (VUMC) have demonstrated for the first time that it is possible to starve a tumor and stop its growth with a newly discovered small compound that blocks uptake of the vital ...

Modular gene enhancer promotes leukemia and regulates effectiveness of chemotherapy

January 18, 2018
Every day, billions of new blood cells are generated in the bone marrow. The gene Myc is known to play an important role in this process, and is also known to play a role in cancer. Scientists from the German Cancer Research ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.