Scarless wound healing—applying lessons learned from fetal stem cells

April 10, 2014, Mary Ann Liebert, Inc
©2014, Mary Ann Liebert, Inc., publishers

In early fetal development, skin wounds undergo regeneration and healing without scar formation. This mechanism of wound healing later disappears, but by studying the fetal stem cells capable of this scarless wound healing, researchers may be able to apply these mechanisms to develop cell-based approaches able to minimize scarring in adult wounds, as described in a Critical Review article published in Advances in Wound Care, a monthly publication from Mary Ann Liebert, Inc., publishers and an Official Journal of the Wound Healing Society.

Michael Longaker, Peter Lorenz, and co-authors from Stanford University School of Medicine and John A. Burns School of Medicine, University of Hawaii, Honolulu, describe a new stem cell that has been identified in fetal skin and blood that may have a role in scarless . In the article "The Role of Stem Cells During Scarless Skin Wound Healing", the authors propose future directions for research to characterize the differences in wound healing mechanisms between fetal and adult skin-specific stem cells.

"This work comes from the pioneers in the field and delineates the opportunities towards scarless healing in adults," says Editor-in-Chief Chandan K. Sen, PhD, Professor of Surgery and Director of the Comprehensive Wound Center and the Center for Regenerative Medicine and Cell-Based Therapies at The Ohio State University Wexner Medical Center, Columbus, OH.

Explore further: Too much of a good thing? Too many 'healing' cells delays wound healing

Related Stories

Too much of a good thing? Too many 'healing' cells delays wound healing

July 1, 2013
Like most other things, you can have too much of a good thing when it comes to wound healing, and new research proves it. According to an article published in the July 2013 issue of the Journal of Leukocyte Biology, wound ...

New finding may help accelerate diabetic wound healing

October 30, 2013
University of Notre Dame researchers have, for the first time, identified the enzymes that are detrimental to diabetic wound healing and those that are beneficial to repair the wound.

Breakthrough research discovery to help heal chronic wounds

December 14, 2012
(Medical Xpress)—The University of Queensland researchers have successfully restored wound healing in a model of diabetes paving the way for new treatments for chronic wounds.

Study identifies molecule critical to healing wounds

November 15, 2013
Skin provides a first line of defense against viruses, bacteria and parasites that might otherwise make people ill. When an injury breaks that barrier, a systematic chain of molecular signaling launches to close the wound ...

Gene and stem cell therapy combination could aid wound healing

October 9, 2013
Johns Hopkins researchers, working with elderly mice, have determined that combining gene therapy with an extra boost of the same stem cells the body already uses to repair itself leads to faster healing of burns and greater ...

Sweat glands play major role in healing human wounds, research shows

November 20, 2012
Turns out the same glands that make you sweat are responsible for another job vital to your health: they help heal wounds.

Recommended for you

Researchers illustrate how muscle growth inhibitor is activated, could aid in treating ALS

January 19, 2018
Researchers at the University of Cincinnati (UC) College of Medicine are part of an international team that has identified how the inactive or latent form of GDF8, a signaling protein also known as myostatin responsible for ...

Bioengineered soft microfibers improve T-cell production

January 18, 2018
T cells play a key role in the body's immune response against pathogens. As a new class of therapeutic approaches, T cells are being harnessed to fight cancer, promising more precise, longer-lasting mitigation than traditional, ...

Weight flux alters molecular profile, study finds

January 17, 2018
The human body undergoes dramatic changes during even short periods of weight gain and loss, according to a study led by researchers at the Stanford University School of Medicine.

Secrets of longevity protein revealed in new study

January 17, 2018
Named after the Greek goddess who spun the thread of life, Klotho proteins play an important role in the regulation of longevity and metabolism. In a recent Yale-led study, researchers revealed the three-dimensional structure ...

The HLF gene protects blood stem cells by maintaining them in a resting state

January 17, 2018
The HLF gene is necessary for maintaining blood stem cells in a resting state, which is crucial for ensuring normal blood production. This has been shown by a new research study from Lund University in Sweden published in ...

Magnetically applied MicroRNAs could one day help relieve constipation

January 17, 2018
Constipation is an underestimated and debilitating medical issue related to the opioid epidemic. As a growing concern, researchers look to new tools to help patients with this side effect of opioid use and aging.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.